8E9E
Rat protein farnesyltransferase in complex with FPP and inhibitor 2f
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | polymer | 377 | 44098.1 | 1 | UniProt (Q04631) Pfam (PF01239) | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase subunit alpha,FTase-alpha,Ras proteins prenyltransferase subunit alpha,Type I protein geranyl-geranyltransferase subunit alpha,GGTase-I-alpha |
| 2 | B (B) | Protein farnesyltransferase subunit beta | polymer | 437 | 48722.3 | 1 | UniProt (Q02293) Pfam (PF00432) | Rattus norvegicus (Norway rat) | FTase-beta,CAAX farnesyltransferase subunit beta,Ras proteins prenyltransferase subunit beta |
| 3 | C, D, E, M (A, B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 4 | Chemie (TRS) | |||
| 4 | F, G, H, L, N... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 5 | I (B) | FARNESYL DIPHOSPHATE | non-polymer | 382.3 | 1 | Chemie (FPP) | |||
| 6 | J (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | K (B) | (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one | non-polymer | 565.4 | 1 | Chemie (XMY) | |||
| 8 | S, T (A, B) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 92820.4 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2060.3 | |
| All* | Total formula weight | 94880.8 |
