1D8E
Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog.
Summary for 1D8E
Entry DOI | 10.2210/pdb1d8e/pdb |
Related | 1d8d 1ft1 1ft2 |
Descriptor | FARNESYLTRANSFERASE (ALPHA SUBUNIT), FARNESYLTRANSFERASE (BETA SUBUNIT), K-RAS4B PEPTIDE SUBSTRATE, ... (6 entities in total) |
Functional Keywords | ftase, pft, pftase, farnesyltransferase, farnesyl transferase, caax, ras, cancer, transferase |
Biological source | Rattus norvegicus (Norway rat) More |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side: P01116 |
Total number of polymer chains | 3 |
Total formula weight | 94537.59 |
Authors | Long, S.B.,Casey, P.J.,Beese, L.S. (deposition date: 1999-10-22, release date: 2000-03-20, Last modification date: 2024-03-13) |
Primary citation | Long, S.B.,Casey, P.J.,Beese, L.S. The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. Structure Fold.Des., 8:209-222, 2000 Cited by PubMed: 10673434DOI: 10.1016/S0969-2126(00)00096-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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