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1D8E

Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog.

Summary for 1D8E
Entry DOI10.2210/pdb1d8e/pdb
Related1d8d 1ft1 1ft2
DescriptorFARNESYLTRANSFERASE (ALPHA SUBUNIT), FARNESYLTRANSFERASE (BETA SUBUNIT), K-RAS4B PEPTIDE SUBSTRATE, ... (6 entities in total)
Functional Keywordsftase, pft, pftase, farnesyltransferase, farnesyl transferase, caax, ras, cancer, transferase
Biological sourceRattus norvegicus (Norway rat)
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Cellular locationCell membrane; Lipid-anchor; Cytoplasmic side: P01116
Total number of polymer chains3
Total formula weight94537.59
Authors
Long, S.B.,Casey, P.J.,Beese, L.S. (deposition date: 1999-10-22, release date: 2000-03-20, Last modification date: 2024-03-13)
Primary citationLong, S.B.,Casey, P.J.,Beese, L.S.
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure Fold.Des., 8:209-222, 2000
Cited by
PubMed: 10673434
DOI: 10.1016/S0969-2126(00)00096-4
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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