1O5M

Structure of FPT bound to the inhibitor SCH66336

Summary for 1O5M

Related1QBQ
DescriptorProtein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (6 entities in total)
Functional Keywordsprotein inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceRattus norvegicus (Norway rat)
Total number of polymer chains2
Total molecular weight93894.93
Authors
Strickland, C.L.,Weber, P.C.,Ganguly, A.K. (deposition date: 2003-09-26, release date: 2003-10-21, Last modification date: 2017-10-04)
Primary citation
Strickland, C.L.,Weber, P.C.,Windsor, W.T.,Wu, Z.,Le, H.V.,Albanese, M.M.,Alvarez, C.S.,Cesarz, D.,del Rosario, J.,Deskus, J.,Mallams, A.K.,Njoroge, F.G.,Piwinski, J.J.,Remiszewski, S.,Rossman, R.R.,Taveras, A.G.,Vibulbhan, B.,Doll, R.J.,Girijavallabhan, V.M.,Ganguly, A.K.
Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure-Activity Relationships
J.Med.Chem., 42:2125-2135, 1999
PubMed: 10377218 (PDB entries with the same primary citation)
DOI: 10.1021/jm990030g
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers80.3%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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