1O5M
Structure of FPT bound to the inhibitor SCH66336
Summary for 1O5M
Entry DOI | 10.2210/pdb1o5m/pdb |
Related | 1QBQ |
Descriptor | Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (6 entities in total) |
Functional Keywords | protein inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 2 |
Total formula weight | 93894.93 |
Authors | Strickland, C.L.,Weber, P.C.,Ganguly, A.K. (deposition date: 2003-09-26, release date: 2003-10-21, Last modification date: 2023-12-27) |
Primary citation | Strickland, C.L.,Weber, P.C.,Windsor, W.T.,Wu, Z.,Le, H.V.,Albanese, M.M.,Alvarez, C.S.,Cesarz, D.,del Rosario, J.,Deskus, J.,Mallams, A.K.,Njoroge, F.G.,Piwinski, J.J.,Remiszewski, S.,Rossman, R.R.,Taveras, A.G.,Vibulbhan, B.,Doll, R.J.,Girijavallabhan, V.M.,Ganguly, A.K. Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure-Activity Relationships J.Med.Chem., 42:2125-2135, 1999 Cited by PubMed: 10377218DOI: 10.1021/jm990030g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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