1O5M
Structure of FPT bound to the inhibitor SCH66336
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein farnesyltransferase alpha subunit | polymer | 377 | 44086.1 | 1 | UniProt (Q04631) Pfam (PF01239) | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase alpha subunit, RAS proteins prenyltransferase alpha, FTase-alpha |
| 2 | B (B) | Protein farnesyltransferase beta subunit | polymer | 437 | 48722.3 | 1 | UniProt (Q02293) Pfam (PF00432) | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta |
| 3 | C (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (B) | FARNESYL DIPHOSPHATE | non-polymer | 382.3 | 1 | Chemie (FPP) | |||
| 5 | E (B) | 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE | non-polymer | 638.8 | 1 | Chemie (336) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 764 | Chemie (HOH) |
Sequence modifications
A: 1 - 377 (UniProt: Q04631)
| PDB | External Database | Details |
|---|---|---|
| Thr 156 | Ile 156 | see remark 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 92808.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1086.6 | |
| All* | Total formula weight | 93894.9 |
