1S64

Rat protein geranylgeranyltransferase type-I complexed with L-778,123 and a sulfate anion

Summary for 1S64

Entry DOI	10.2210/pdb1s64/pdb
Related	1JCQ 1LD7 1N4P 1N4Q 1O5M 1S63
Descriptor	Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Geranylgeranyl transferase type I beta subunit, ZINC ION, ... (8 entities in total)
Functional Keywords	l-778, 123, protein geranylgeranyltransferase type-i, protein prenylation, lipid modification, drug, transferase
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	12
Total formula weight	524280.54
Authors	Reid, T.S.,Long, S.B.,Beese, L.S. (deposition date: 2004-01-22, release date: 2004-07-27, Last modification date: 2023-08-23)
Primary citation	Reid, T.S.,Long, S.B.,Beese, L.S. Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes. Biochemistry, 43:9000-9008, 2004 Cited by PubMed: 15248757 DOI: 10.1021/bi049280b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation