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1S64

Rat protein geranylgeranyltransferase type-I complexed with L-778,123 and a sulfate anion

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C, E, G, I...
(A, C, E, G, I...)
Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunitpolymer37744098.16UniProt (Q04631)
Pfam (PF01239)
Rattus norvegicus (Norway rat)CAAX farnesyltransferase alpha subunit, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase alpha subunit, GGTase-I-alpha
2B, D, F, H, J...
(B, D, F, H, J...)
Geranylgeranyl transferase type I beta subunitpolymer37742466.26UniProt (P53610)
Pfam (PF00432)
Rattus norvegicus (Norway rat)Type I protein geranyl-geranyltransferase beta subunit, GGTase-I-beta
3CA, IA, M, OA, R...
(H, J, B, L, D...)
ZINC IONnon-polymer65.46Chemie (ZN)
4EA, KA, N, QA, T...
(H, J, B, L, D...)
SULFATE IONnon-polymer96.16Chemie (SO4)
5FA, LA, O, RA, U...
(H, J, B, L, D...)
4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILEnon-polymer405.96Chemie (778)
6AA, GA, MA, P, SA...
(F, H, J, B, L...)
2-(N-MORPHOLINO)-ETHANESULFONIC ACIDnon-polymer195.26Chemie (MES)
7BA, DA, HA, JA, NA...
(G, H, I, J, K...)
CHLORIDE IONnon-polymer35.59Chemie (CL)
8AB, BB, CB, DB, EB...
(H, I, J, K, L...)
waterwater18.01375Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight519385.9
Non-Polymers*Number of molecules33
Total formula weight4894.6
All*Total formula weight524280.5
*Water molecules are not included.

243531

PDB entries from 2025-10-22

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