PDB: 865 件ウェブページステータス検索Chemie searchBIRD

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3CX7	Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP-AlF4 分子名称: GUANOSINE-5'-DIPHOSPHATE, Glutamate Transporter Associated Protein 48, Guanine Nucleotide-Binding Protein Galpha 13, ... 著者 Sprang, S.R, Chen, Z. 登録日 2008-04-23 公開日 2008-10-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF. Structure, 16, 2008
3CX6	Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein alpha-13 subunit, MAGNESIUM ION, ... 著者 Sprang, S.R, Chen, Z. 登録日 2008-04-23 公開日 2008-10-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF. Structure, 16, 2008
6VU5	Structure of G-alpha-q bound to its chaperone Ric-8A 分子名称: Guanine nucleotide-binding protein G(q) subunit alpha, Resistance to inhibitors of cholinesterase-8A (Ric-8A) 著者 Seven, A.B, Hilger, D. 登録日 2020-02-14 公開日 2020-03-18 最終更新日 2020-03-25 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of G alpha Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. Cell Rep, 30, 2020
6VU8	Structure of G-alpha-i bound to its chaperone Ric-8A 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1, Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) 著者 Seven, A.B, Hilger, D. 登録日 2020-02-14 公開日 2020-03-18 最終更新日 2020-03-25 実験手法 ELECTRON MICROSCOPY (4.14 Å) 主引用文献 Structures of G alpha Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. Cell Rep, 30, 2020
1AGR	COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4 分子名称: CITRIC ACID, GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), GUANOSINE-5'-DIPHOSPHATE, ... 著者 Tesmer, J.J.G, Sprang, S.R. 登録日 1997-03-25 公開日 1997-06-16 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell(Cambridge,Mass.), 89, 1997
8EL7	CryoEM structure of Resistance to Inhibitors of Cholinesterase-8B (Ric-8B) in complex with G alpha s 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Isoform 1 of Synembryn-B 著者 Papasergi-Scott, M.M, Skiniotis, G. 登録日 2022-09-23 公開日 2023-03-01 最終更新日 2023-05-17 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structures of Ric-8B in complex with G alpha protein folding clients reveal isoform specificity mechanisms. Structure, 31, 2023
8EL8	CryoEM structure of Resistance to Inhibitors of Cholinesterase-8B (Ric-8B) in complex with olfactory G protein alpha olf 分子名称: Guanine nucleotide-binding protein G(olf) subunit alpha, Isoform 1 of Synembryn-B 著者 Papasergi-Scott, M.M, Skiniotis, G. 登録日 2022-09-23 公開日 2023-03-01 最終更新日 2023-05-17 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structures of Ric-8B in complex with G alpha protein folding clients reveal isoform specificity mechanisms. Structure, 31, 2023
7AD3	Class D GPCR Ste2 dimer coupled to two G proteins 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-factor mating pheromone, CHOLESTEROL HEMISUCCINATE, ... 著者 Velazhahan, V, Tate, C. 登録日 2020-09-14 公開日 2020-12-09 最終更新日 2021-01-13 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of the class D GPCR Ste2 dimer coupled to two G proteins. Nature, 589, 2021
3MAA	Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(l-Thiophosphate) and Low Ca Concentration 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, Adenylate cyclase type 2, ... 著者 Mou, T.-C, Sprang, S.R. 登録日 2010-03-23 公開日 2010-04-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for inhibition of mammalian adenylyl cyclase by calcium. Biochemistry, 48, 2009
2BCJ	Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits 分子名称: G-protein-coupled receptor kinase 2, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Tesmer, J.J.G. 登録日 2005-10-19 公開日 2005-12-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3.061 Å) 主引用文献 Snapshot of Activated G Proteins at the Membrane: The Gq-GRK2-G Complex Science, 310, 2005
5G53	Structure of the adenosine A2A receptor bound to an engineered G protein 分子名称: ADENOSINE RECEPTOR A2A, ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Carpenter, B, Nehme, R, Warne, T, Leslie, A.G.W, Tate, C.G. 登録日 2016-05-19 公開日 2016-08-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structure of the Adenosine A2A Receptor Bound to an Engineered G Protein Nature, 536, 2016
5TDH	The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Liu, P, Jia, M.-Z, Zhou, X.E, de Waal, P.W, Dickson, B.M, Liu, B, Hou, L, Yin, Y.-T, Kang, Y.-Y, Shi, Y, Melcher, K, Xu, H.E, Jiang, Y. 登録日 2016-09-19 公開日 2016-11-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The structural basis of the dominant negative phenotype of the G alpha i1 beta 1 gamma 2 G203A/A326S heterotrimer Acta Pharmacol.Sin., 37, 2016
5UZ7	Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex 分子名称: Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Liang, Y.L, Khoshouei, M, Radjainia, M, Zhang, Y, Glukhova, A, Tarrasch, J, Thal, D.M, Furness, S.G.B, Christopoulos, G, Coudrat, T, Danev, R, Baumeister, W, Miller, L.J, Christopoulos, A, Kobilka, B.K, Wootten, D, Skiniotis, G, Sexton, P.M. 登録日 2017-02-24 公開日 2017-05-03 最終更新日 2018-07-18 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Phase-plate cryo-EM structure of a class B GPCR-G-protein complex. Nature, 546, 2017
5VAI	Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein 分子名称: Glucagon-like peptide 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, Y, Sun, B, Feng, D, Hu, H, Chu, M, Qu, Q, Tarrasch, J.T, Li, S, Kobilka, T.S, Kobilka, B.K, Skiniotis, G. 登録日 2017-03-27 公開日 2017-05-24 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature, 546, 2017
5KDO	Heterotrimeric complex of the 4 alanine insertion variant of the Gi alpha1 subunit and the Gbeta1-Ggamma1 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ... 著者 Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. 登録日 2016-06-08 公開日 2016-08-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor. J.Biol.Chem., 291, 2016
2RGN	Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... 著者 Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. 登録日 2007-10-04 公開日 2008-01-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science, 318, 2007
3SN6	Crystal structure of the beta2 adrenergic receptor-Gs protein complex 分子名称: 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid antibody VHH fragment, Endolysin,Beta-2 adrenergic receptor, ... 著者 Rasmussen, S.G.F, DeVree, B.T, Zou, Y, Kruse, A.C, Chung, K.Y, Kobilka, T.S, Thian, F.S, Chae, P.S, Pardon, E, Calinski, D, Mathiesen, J.M, Shah, S.T.A, Lyons, J.A, Caffrey, M, Gellman, S.H, Steyaert, J, Skiniotis, G, Weis, W.I, Sunahara, R.K, Kobilka, B.K. 登録日 2011-06-28 公開日 2011-07-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structure of the beta2 adrenergic receptor-Gs protein complex Nature, 477, 2011
6E3Y	Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor 分子名称: Calcitonin gene-related peptide 1, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liang, Y.L, Khoshouei, M, Deganutti, G, Glukhova, A, Koole, C, Peat, T.S, Radjainia, M, Plitzko, J.M, Baumeister, W, Miller, L.J, Hay, D.L, Christopoulos, A, Reynolds, C.A, Wootten, D, Sexton, P.M. 登録日 2018-07-16 公開日 2018-09-19 最終更新日 2020-01-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor. Nature, 561, 2018
6R4P	Structure of a soluble domain of adenylyl cyclase bound to an activated stimulatory G protein 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Korkhov, V.M, Qi, C. 登録日 2019-03-22 公開日 2019-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein. Science, 364, 2019
6EG8	Structure of the GDP-bound Gs heterotrimer 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Hilger, D, Liu, X, Aschauer, P, Kobilka, B.K. 登録日 2018-08-19 公開日 2019-06-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Insights into the Process of GPCR-G Protein Complex Formation. Cell, 177, 2019
4GNK	Crystal structure of Galphaq in complex with full-length human PLCbeta3 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Lyon, A.M, Tesmer, J.J.G. 登録日 2012-08-17 公開日 2013-02-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Full-length G alpha (q)-phospholipase C-beta 3 structure reveals interfaces of the C-terminal coiled-coil domain. Nat.Struct.Mol.Biol., 20, 2013
6R4O	Structure of a truncated adenylyl cyclase bound to MANT-GTP, forskolin and an activated stimulatory Galphas protein 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, ... 著者 Qi, C, Sorrentino, S, Medalia, O, Korkhov, V.M. 登録日 2019-03-22 公開日 2019-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein. Science, 364, 2019
2GVZ	Crystal Structure of Complex of Gs- with The Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with MANT-ATP and Mn 分子名称: 3'-O-[2-(METHYLAMINO)BENZOYL]ADENOSINE 5'-(TETRAHYDROGEN TRIPHOSPHATE), 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 2, ... 著者 Mou, T.-C, Sprang, S.R. 登録日 2006-05-03 公開日 2006-07-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.27 Å) 主引用文献 Broad specificity of Mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors. Mol.Pharmacol., 70, 2006
2GVD	Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With TNP-ATP and Mn 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 2, Adenylate cyclase type 5, ... 著者 Mou, T.-C, Sprang, S.R. 登録日 2006-05-02 公開日 2006-07-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Broad specificity of Mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors. Mol.Pharmacol., 70, 2006
6R3Q	The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Korkhov, V.M, Qi, C. 登録日 2019-03-20 公開日 2019-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein. Science, 364, 2019

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