3G82
Complex of GS-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with MANT-ITP and Mn
Summary for 3G82
Entry DOI | 10.2210/pdb3g82/pdb |
Related | 1TL7 2GVD 2GVZ |
Descriptor | Adenylate cyclase type 5, Adenylate cyclase type 2, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (10 entities in total) |
Functional Keywords | adenylyl cyclase, mant-itp, alternative splicing, camp biosynthesis, glycoprotein, lyase, magnesium, membrane, metal-binding, phosphoprotein, transmembrane, cell membrane, gtp-binding, lipoprotein, nucleotide-binding, palmitate, transducer, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Canis lupus familiaris (dogs) More |
Cellular location | Membrane; Multi-pass membrane protein: P30803 P26769 Cell membrane; Lipid-anchor (By similarity): P04896 |
Total number of polymer chains | 3 |
Total formula weight | 96773.77 |
Authors | Huebner, M.,Mou, T.-C.,Sprang, S.R.,Seifert, R. (deposition date: 2009-02-11, release date: 2010-02-16, Last modification date: 2023-09-06) |
Primary citation | Huebner, M.,Geduhn, J.,Pinto, C.,Mou, T.-C.,Konig, B.,Sprang, S.R.,Seifert, R. 2',3'-(O)-(N-Methyl)anthraniloyl-inosine 5'-triphosphate is the Most Potent Adenylyl Cyclase 1 and 5 Inhibitor Known so far and Effectively Promotes Catalytic Subunit Assembly in the Absence of Forskolin To be Published, |
Experimental method | X-RAY DIFFRACTION (3.11 Å) |
Structure validation
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