3G82

Complex of GS-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with MANT-ITP and Mn

Summary for 3G82

• Entry DOI: 10.2210/pdb3g82/pdb
• Related: 1TL7 2GVD 2GVZ
• Descriptor: Adenylate cyclase type 5, Adenylate cyclase type 2, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (10 entities in total)
• Functional Keywords: adenylyl cyclase, mant-itp, alternative splicing, camp biosynthesis, glycoprotein, lyase, magnesium, membrane, metal-binding, phosphoprotein, transmembrane, cell membrane, gtp-binding, lipoprotein, nucleotide-binding, palmitate, transducer, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Canis lupus familiaris (dogs); More
• Cellular location: Membrane; Multi-pass membrane protein: P30803 P26769; Cell membrane; Lipid-anchor (By similarity): P04896
• Total number of polymer chains: 3
• Total formula weight: 96773.77

Authors

Huebner, M.,Mou, T.-C.,Sprang, S.R.,Seifert, R. (deposition date: 2009-02-11, release date: 2010-02-16, Last modification date: 2023-09-06)

• Primary citation: Huebner, M.,Geduhn, J.,Pinto, C.,Mou, T.-C.,Konig, B.,Sprang, S.R.,Seifert, R.; 2',3'-(O)-(N-Methyl)anthraniloyl-inosine 5'-triphosphate is the Most Potent Adenylyl Cyclase 1 and 5 Inhibitor Known so far and Effectively Promotes Catalytic Subunit Assembly in the Absence of Forskolin; To be Published,

Experimental method

X-RAY DIFFRACTION (3.11 Å)