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2RGN

Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA

Summary for 2RGN
Entry DOI10.2210/pdb2rgn/pdb
Related2bcj
DescriptorGuanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, Rho guanine nucleotide exchange factor 25, Transforming protein RhoA, ... (7 entities in total)
Functional Keywordsheterotrimeric g-protein, small molecular weight g-protein, signaling complex, protein-protein complex, rhogef, rhoa, galphaq, galpha-q, p63rhogef, gq, gtp-binding, lipoprotein, nucleotide-binding, palmitate, transducer, adp-ribosylation, cytoskeleton, magnesium, membrane, methylation, prenylation, proto-oncogene, signaling protein complex
Biological sourceRattus norvegicus (Rat)
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Cellular locationCell membrane : Q86VW2
Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
Total number of polymer chains6
Total formula weight209214.51
Authors
Shankaranarayanan, A.,Nance, M.R.,Tesmer, J.J.G. (deposition date: 2007-10-04, release date: 2008-01-15, Last modification date: 2023-08-30)
Primary citationLutz, S.,Shankaranarayanan, A.,Coco, C.,Ridilla, M.,Nance, M.R.,Vettel, C.,Baltus, D.,Evelyn, C.R.,Neubig, R.R.,Wieland, T.,Tesmer, J.J.
Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science, 318:1923-1927, 2007
Cited by
PubMed: 18096806
DOI: 10.1126/science.1147554
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.5 Å)
Structure validation

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