2RGN
Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 353 | 41298.9 | 2 | UniProt (P10824) Pfam (PF00503) UniProt (by SIFTS) (P21279) | Rattus norvegicus (Rat) | Adenylate cyclase-inhibiting G alpha protein,Guanine nucleotide-binding protein alpha-q |
| 2 | B, E (B, E) | Rho guanine nucleotide exchange factor 25 | polymer | 354 | 40605.4 | 2 | UniProt (Q86VW2) Pfam (PF00621) Pfam (PF22697) | Homo sapiens (Human) | Guanine nucleotide exchange factor GEFT,Rac/Cdc42/Rho exchange factor GEFT,RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT,p63RhoGEF |
| 3 | C, F (C, F) | Transforming protein RhoA | polymer | 196 | 22132.5 | 2 | UniProt (P61586) Pfam (PF00071) | Homo sapiens (Human) | Rho cDNA clone 12,h12 |
| 4 | G, J (A, D) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) PubChem (5311325) | |||
| 5 | H, K (A, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | I, L (A, D) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 7 | M, N (A, D) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, D: 7 - 34 (UniProt: P10824)
A, D: 37 - 359 (PDB: 2RGN)
C, F: 1 - 193 (UniProt: P61586)
| PDB | External Database | Details |
|---|---|---|
| Arg 35 | - | linker |
| Ser 36 | - | linker |
C, F: 1 - 193 (UniProt: P61586)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 208073.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1141.0 | |
| All* | Total formula weight | 209214.5 |
