PDB: 1375 件ウェブページステータス検索Chemie searchBIRD

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1O5M	Structure of FPT bound to the inhibitor SCH66336 分子名称: 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, FARNESYL DIPHOSPHATE, Protein farnesyltransferase alpha subunit, ... 著者 Strickland, C.L, Weber, P.C, Ganguly, A.K. 登録日 2003-09-26 公開日 2003-10-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure-Activity Relationships J.Med.Chem., 42, 1999
1TN8	Protein Farnesyltransferase Complexed with a H-Ras Peptide Substrate and a FPP Analog at 2.25A Resolution 分子名称: ACETIC ACID, Protein farnesyltransferase beta subunit, Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, ... 著者 Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. 登録日 2004-06-11 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
1TNY	Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a FREKKFFCAIL Peptide Derived from the Heterotrimeric G Protein Gamma-2 Subunit 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, ... 著者 S Reid, T, Terry, K.L, Casey, P.J, Beese, L.S. 登録日 2004-06-11 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
1TN7	Protein Farnesyltransferase Complexed with a TC21 Peptide Substrate and a FPP Analog at 2.3A Resolution 分子名称: ACETIC ACID, Fusion protein, Protein farnesyltransferase alpha subunit, ... 著者 Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. 登録日 2004-06-11 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
1TNU	Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a GCINCCKVL Peptide Derived from RhoB 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, ... 著者 Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. 登録日 2004-06-11 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
1TNB	Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a substrate KKSKTKCVIF Peptide Derived from TC21 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, ... 著者 Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. 登録日 2004-06-11 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
1TNO	Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a KKKSKTKCVIM Peptide Derived from K-Ras4B 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, ... 著者 Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. 登録日 2004-06-11 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343, 2004
2HQW	Crystal Structure of Ca2+/Calmodulin bound to NMDA Receptor NR1C1 peptide 分子名称: CALCIUM ION, Calmodulin, Glutamate NMDA receptor subunit zeta 1 著者 Akyol, Z, Gakhar, L, Sorensen, B.R, Hell, J.H, Shea, M.A. 登録日 2006-07-19 公開日 2007-11-13 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences between Homologous Domains. Structure, 15, 2007
1IS7	Crystal structure of rat GTPCHI/GFRP stimulatory complex 分子名称: GTP Cyclohydrolase I, GTP Cyclohydrolase I Feedback Regulatory Protein, PHENYLALANINE, ... 著者 Maita, N, Okada, K, Hatakeyama, K, Hakoshima, T. 登録日 2001-11-18 公開日 2002-02-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP. Proc.Natl.Acad.Sci.USA, 99, 2002
6IBT	Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclophellitol aziridine ME737 分子名称: (1~{S},2~{S},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Rowland, R.J, Wu, L, Davies, G.J. 登録日 2018-11-30 公開日 2019-10-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease Chem Sci, 2019
1IS8	Crystal structure of rat GTPCHI/GFRP stimulatory complex plus Zn 分子名称: GTP Cyclohydrolase I, GTP Cyclohydrolase I Feedback Regulatory Protein, PHENYLALANINE, ... 著者 Maita, N, Okada, K, Hatakeyama, K, Hakoshima, T. 登録日 2001-11-18 公開日 2002-02-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP. Proc.Natl.Acad.Sci.USA, 99, 2002
4G27	Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea 分子名称: 1-phenylurea, CALCIUM ION, Calmodulin, ... 著者 Zhang, M, Pascal, J.M, Zhang, J.-F. 登録日 2012-07-11 公開日 2012-09-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels. Nat Commun, 3, 2012
6IBM	Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclosulfate ME776 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... 著者 Rowland, R.J, Wu, L, Davies, G.J. 登録日 2018-11-30 公開日 2019-10-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease Chem Sci, 2019
6IBK	Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclosulfamidate ME763 分子名称: (3~{a}~{R},4~{S},5~{S},6~{S},7~{R},7~{a}~{S})-7-(hydroxymethyl)-2,2-bis(oxidanylidene)-3~{a},4,5,6,7,7~{a}-hexahydro-3~{H}-benzo[d][1,2,3]oxathiazole-4,5,6-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Rowland, R.J, Wu, L, Davies, G.J. 登録日 2018-11-30 公開日 2019-10-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease Chem Sci, 2019
8E9E	Rat protein farnesyltransferase in complex with FPP and inhibitor 2f 分子名称: (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... 著者 Wang, Y, Shi, Y, Beese, L.S. 登録日 2022-08-26 公開日 2022-10-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.844 Å) 主引用文献 Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
4GTQ	FTase in complex with BMS analogue 12 分子名称: 4-({(3R)-7-cyano-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl benzylcarbamate, FARNESYL DIPHOSPHATE, Protein farnesyltransferase subunit beta, ... 著者 Guo, Z, Stigter, E.A, Bon, R.S, Waldmann, H, Blankenfeldt, W, Goody, R.S. 登録日 2012-08-29 公開日 2012-10-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Development of Selective, Potent RabGGTase Inhibitors J.Med.Chem., 55, 2012
4G28	Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and EBIO-1 分子名称: 1-ethyl-1,3-dihydro-2H-benzimidazol-2-one, CALCIUM ION, Calmodulin, ... 著者 Zhang, M, Pascal, J.M, Zhang, J.-F. 登録日 2012-07-11 公開日 2012-09-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels. Nat Commun, 3, 2012
4IL1	Crystal Structure of the Rat Calcineurin 分子名称: CALCIUM ION, Calmodulin, Calcineurin subunit B type 1, ... 著者 Ye, Q, Faucher, F, Jia, Z. 登録日 2012-12-28 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of calcineurin activation by calmodulin. Cell Signal, 25, 2013
4J9Z	Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and NS309 分子名称: (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin, ... 著者 Zhang, M, Pascal, J.M, Zhang, J.-F. 登録日 2013-02-17 公開日 2013-03-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation. Proc.Natl.Acad.Sci.USA, 110, 2013
4J9Y	Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant 分子名称: CALCIUM ION, Calmodulin, GLYCEROL, ... 著者 Zhang, M, Pascal, J.M, Zhang, J.-F. 登録日 2013-02-17 公開日 2013-03-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation. Proc.Natl.Acad.Sci.USA, 110, 2013
4OY4	calcium-free CaMPARI v0.2 分子名称: Chimera protein of Calmodulin, GPF-like protein EosFP, and Myosin light chain kinase, ... 著者 Fosque, B.F, Schreiter, E.R. 登録日 2014-02-10 公開日 2015-02-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Neural circuits. Labeling of active neural circuits in vivo with designed calcium integrators. Science, 347, 2015
1FG9	3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER 分子名称: INTERFERON GAMMA, INTERFERON-GAMMA RECEPTOR ALPHA CHAIN 著者 Thiel, D.J, le Du, M.-H, Walter, R.L, D'Arcy, A, Chene, C, Fountoulakis, M, Garotta, G, Winkler, F.K, Ealick, S.E. 登録日 2000-07-28 公開日 2000-08-11 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure Fold.Des., 8, 2000
1FYH	1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR 分子名称: CHLORIDE ION, Interferon gamma, Interferon gamma receptor 1 著者 Randal, M, Kossiakoff, A.A. 登録日 2000-09-29 公開日 2000-10-11 最終更新日 2017-06-21 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex. Structure, 9, 2001
7KW7	Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR 分子名称: ADENOSINE-5'-DIPHOSPHATE, Glucocorticoid receptor, Heat shock 70 kDa protein 1A, ... 著者 Wang, R.Y, Noddings, C.M, Kirschke, E, Myasnikov, A, Johnson, J.L, Agard, D.A. 登録日 2020-11-30 公開日 2021-12-08 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature, 601, 2022
3E32	Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 2 分子名称: FARNESYL DIPHOSPHATE, N-benzyl-N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)-1-methyl-1H-imidazole-4-sulfonamide, Protein farnesyltransferase subunit beta, ... 著者 Hast, M.A, Beese, L.S. 登録日 2008-08-06 公開日 2009-03-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem.Biol., 16, 2009

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