6IBT

Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclophellitol aziridine ME737

Summary for 6IBT

• Entry DOI: 10.2210/pdb6ibt/pdb
• Related: 6IBK 6IBM 6IBR
• Descriptor: Alpha-galactosidase A, ACETATE ION, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: hydrolase, glycosidase, galactose, carbohydrate
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 95677.59

Authors

Rowland, R.J.,Wu, L.,Davies, G.J. (deposition date: 2018-11-30, release date: 2019-10-09, Last modification date: 2024-01-24)

• Primary citation: Artola, M.,Hedberg, C.,Rowland, R.J.,Wu, L.,Raich, L.,Ferraz, M.J.,Kytidou, K.,Marel, G.A.,Codee, J.D.C.,Rovira, C.,Aerts, J.M.F.G.,Davies, G.J.,Overkleeft, H.S.; Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease; Chem Sci, 2019; DOI: 10.1039/C9SC03342D

Experimental method

X-RAY DIFFRACTION (2.04 Å)