6IBT
Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclophellitol aziridine ME737
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Alpha-galactosidase A | polymer | 398 | 45394.5 | 2 | UniProt (P06280) Pfam (PF16499) Pfam (PF17450) In PDB | Homo sapiens (Human) | Alpha-D-galactosidase A,Alpha-D-galactoside galactohydrolase,Melibiase |
| 2 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 3 | D, E | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 4 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 7 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 8 | A, B | (1~{S},2~{S},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol | non-polymer | 175.2 | 2 | Chemie (H9T) | |||
| 9 | B, A | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 10 | B, A | ACETATE ION | non-polymer | 59.0 | 6 | Chemie (ACT) | |||
| 11 | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 90789.1 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2508.3 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 2380.2 | |
| All* | Total formula weight | 95677.6 |
