6IBM
Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclosulfate ME776
Summary for 6IBM
Entry DOI | 10.2210/pdb6ibm/pdb |
Related | 6IBK |
Descriptor | Alpha-galactosidase A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | hydrolase, glycosidase, galactose, carbohydrate |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 97160.99 |
Authors | Rowland, R.J.,Wu, L.,Davies, G.J. (deposition date: 2018-11-30, release date: 2019-10-09, Last modification date: 2024-01-24) |
Primary citation | Artola, M.,Hedberg, C.,Rowland, R.J.,Wu, L.,Raich, L.,Ferraz, M.J.,Kytidou, K.,Marel, G.A.,Codee, J.D.C.,Rovira, C.,Aerts, J.M.F.G.,Davies, G.J.,Overkleeft, H.S. Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease Chem Sci, 2019 Cited by DOI: 10.1039/C9SC03342DPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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