4GTQ
FTase in complex with BMS analogue 12
Summary for 4GTQ
Entry DOI | 10.2210/pdb4gtq/pdb |
Related | 4GTM 4GTO 4GTP 4GTR 4GTS 4GTT 4GTV |
Descriptor | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, ZINC ION, ... (6 entities in total) |
Functional Keywords | protein prenylation, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (rat) More |
Total number of polymer chains | 2 |
Total formula weight | 92972.00 |
Authors | Guo, Z.,Stigter, E.A.,Bon, R.S.,Waldmann, H.,Blankenfeldt, W.,Goody, R.S. (deposition date: 2012-08-29, release date: 2012-10-24, Last modification date: 2023-11-08) |
Primary citation | Stigter, E.A.,Guo, Z.,Bon, R.S.,Wu, Y.W.,Choidas, A.,Wolf, A.,Menninger, S.,Waldmann, H.,Blankenfeldt, W.,Goody, R.S. Development of Selective, Potent RabGGTase Inhibitors J.Med.Chem., 55:8330-8340, 2012 Cited by PubMed: 22963166DOI: 10.1021/jm300624s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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