1FYH

1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR

Summary for 1FYH

• Entry DOI: 10.2210/pdb1fyh/pdb
• Related: 1D9C 1EKU 1FG9
• Descriptor: Interferon gamma, Interferon gamma receptor 1, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: cytokine-receptor complex, fibronectin type-iii, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P01579; Cell membrane ; Single-pass type I membrane protein : P15260
• Total number of polymer chains: 4
• Total formula weight: 112128.32

Authors

Randal, M.,Kossiakoff, A.A. (deposition date: 2000-09-29, release date: 2000-10-11, Last modification date: 2024-11-06)

Primary citation

Randal, M.,Kossiakoff, A.A.
The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex.
Structure, 9:155-163, 2001

PubMed Abstract: Interferon-gamma (IFN-gamma) is a homodimeric cytokine that exerts its various activities by inducing the aggregation of two different receptors. The alpha chain receptor (IFN-gammaRalpha) is a high affinity receptor that binds to IFN-gamma in a symmetric bivalent manner to form a stable, intermediate 1:2 complex. This intermediate forms a binding template for the subsequent binding of two copies of the second receptor, beta chain receptor (IFN-gammaRbeta), producing the active 1:2:2 signaling complex.

PubMed: 11250200
DOI: 10.1016/S0969-2126(01)00567-6

Experimental method

X-RAY DIFFRACTION (2.04 Å)