1FYH
1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, D) | Interferon gamma | polymer | 258 | 30146.3 | 2 | UniProt (P01579) Pfam (PF00714) | Homo sapiens (Human) | IFN-gamma,Immune interferon |
| 2 | B, D (B, E) | Interferon gamma receptor 1 | polymer | 229 | 25900.2 | 2 | UniProt (P15260) Pfam (PF01108) Pfam (PF07140) | Homo sapiens (Human) | IFN-gamma-R1,CDw119,Interferon gamma receptor alpha-chain,IFN-gamma-R-alpha |
| 3 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | F, G, H, I (A, B, D, E) | water | water | 18.0 | 481 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 120 (UniProt: P01579)
A, D: 205 - 333 (UniProt: P01579)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Asp 111 | His 134 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 121 | - | linker |
| Ala 122 | - | linker |
| Asn 123 | - | linker |
| Val 124 | - | linker |
| Ser 201 | - | linker |
| Gly 202 | - | linker |
| Glu 203 | - | linker |
| Phe 204 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 112092.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 112128.3 |
