Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1FYH

1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001774biological_processmicroglial cell activation
A0001819biological_processpositive regulation of cytokine production
A0002250biological_processadaptive immune response
A0002281biological_processmacrophage activation involved in immune response
A0005125molecular_functioncytokine activity
A0005133molecular_functiontype II interferon receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006915biological_processapoptotic process
A0006955biological_processimmune response
A0006959biological_processhumoral immune response
A0007166biological_processcell surface receptor signaling pathway
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008284biological_processpositive regulation of cell population proliferation
A0009615biological_processresponse to virus
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010634biological_processpositive regulation of epithelial cell migration
A0019222biological_processregulation of metabolic process
A0030225biological_processmacrophage differentiation
A0030857biological_processnegative regulation of epithelial cell differentiation
A0031334biological_processpositive regulation of protein-containing complex assembly
A0032700biological_processnegative regulation of interleukin-17 production
A0032722biological_processpositive regulation of chemokine production
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032735biological_processpositive regulation of interleukin-12 production
A0032747biological_processpositive regulation of interleukin-23 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032834biological_processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
A0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
A0034393biological_processpositive regulation of smooth muscle cell apoptotic process
A0038196biological_processtype III interferon-mediated signaling pathway
A0042307biological_processpositive regulation of protein import into nucleus
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0045348biological_processpositive regulation of MHC class II biosynthetic process
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045672biological_processpositive regulation of osteoclast differentiation
A0045821biological_processpositive regulation of glycolytic process
A0045892biological_processnegative regulation of DNA-templated transcription
A0048143biological_processastrocyte activation
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050729biological_processpositive regulation of inflammatory response
A0050766biological_processpositive regulation of phagocytosis
A0050769biological_processpositive regulation of neurogenesis
A0050796biological_processregulation of insulin secretion
A0051044biological_processpositive regulation of membrane protein ectodomain proteolysis
A0051607biological_processdefense response to virus
A0051712biological_processpositive regulation of killing of cells of another organism
A0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
A0060333biological_processtype II interferon-mediated signaling pathway
A0060550biological_processpositive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
A0060552biological_processpositive regulation of fructose 1,6-bisphosphate metabolic process
A0060557biological_processpositive regulation of vitamin D biosynthetic process
A0060559biological_processpositive regulation of calcidiol 1-monooxygenase activity
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0090312biological_processpositive regulation of protein deacetylation
A0097191biological_processextrinsic apoptotic signaling pathway
A0098586biological_processcellular response to virus
A0150076biological_processneuroinflammatory response
A1900222biological_processnegative regulation of amyloid-beta clearance
A1901857biological_processpositive regulation of cellular respiration
A1902004biological_processpositive regulation of amyloid-beta formation
A1902948biological_processnegative regulation of tau-protein kinase activity
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1903543biological_processpositive regulation of exosomal secretion
A1904440biological_processpositive regulation of iron ion import across plasma membrane
A1904783biological_processpositive regulation of NMDA glutamate receptor activity
A1904798biological_processpositive regulation of core promoter binding
A2000273biological_processpositive regulation of signaling receptor activity
A2000309biological_processpositive regulation of tumor necrosis factor (ligand) superfamily member 11 production
B0004896molecular_functioncytokine receptor activity
B0060333biological_processtype II interferon-mediated signaling pathway
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001774biological_processmicroglial cell activation
D0001819biological_processpositive regulation of cytokine production
D0002250biological_processadaptive immune response
D0002281biological_processmacrophage activation involved in immune response
D0005125molecular_functioncytokine activity
D0005133molecular_functiontype II interferon receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006915biological_processapoptotic process
D0006955biological_processimmune response
D0006959biological_processhumoral immune response
D0007166biological_processcell surface receptor signaling pathway
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0008284biological_processpositive regulation of cell population proliferation
D0009615biological_processresponse to virus
D0010508biological_processpositive regulation of autophagy
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010634biological_processpositive regulation of epithelial cell migration
D0019222biological_processregulation of metabolic process
D0030225biological_processmacrophage differentiation
D0030857biological_processnegative regulation of epithelial cell differentiation
D0031334biological_processpositive regulation of protein-containing complex assembly
D0032700biological_processnegative regulation of interleukin-17 production
D0032722biological_processpositive regulation of chemokine production
D0032731biological_processpositive regulation of interleukin-1 beta production
D0032735biological_processpositive regulation of interleukin-12 production
D0032747biological_processpositive regulation of interleukin-23 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032834biological_processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
D0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
D0034393biological_processpositive regulation of smooth muscle cell apoptotic process
D0038196biological_processtype III interferon-mediated signaling pathway
D0042307biological_processpositive regulation of protein import into nucleus
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0045348biological_processpositive regulation of MHC class II biosynthetic process
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0045672biological_processpositive regulation of osteoclast differentiation
D0045821biological_processpositive regulation of glycolytic process
D0045892biological_processnegative regulation of DNA-templated transcription
D0048143biological_processastrocyte activation
D0048662biological_processnegative regulation of smooth muscle cell proliferation
D0050729biological_processpositive regulation of inflammatory response
D0050766biological_processpositive regulation of phagocytosis
D0050769biological_processpositive regulation of neurogenesis
D0050796biological_processregulation of insulin secretion
D0051044biological_processpositive regulation of membrane protein ectodomain proteolysis
D0051607biological_processdefense response to virus
D0051712biological_processpositive regulation of killing of cells of another organism
D0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
D0060333biological_processtype II interferon-mediated signaling pathway
D0060550biological_processpositive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
D0060552biological_processpositive regulation of fructose 1,6-bisphosphate metabolic process
D0060557biological_processpositive regulation of vitamin D biosynthetic process
D0060559biological_processpositive regulation of calcidiol 1-monooxygenase activity
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0090312biological_processpositive regulation of protein deacetylation
D0097191biological_processextrinsic apoptotic signaling pathway
D0098586biological_processcellular response to virus
D0150076biological_processneuroinflammatory response
D1900222biological_processnegative regulation of amyloid-beta clearance
D1901857biological_processpositive regulation of cellular respiration
D1902004biological_processpositive regulation of amyloid-beta formation
D1902948biological_processnegative regulation of tau-protein kinase activity
D1903078biological_processpositive regulation of protein localization to plasma membrane
D1903543biological_processpositive regulation of exosomal secretion
D1904440biological_processpositive regulation of iron ion import across plasma membrane
D1904783biological_processpositive regulation of NMDA glutamate receptor activity
D1904798biological_processpositive regulation of core promoter binding
D2000273biological_processpositive regulation of signaling receptor activity
D2000309biological_processpositive regulation of tumor necrosis factor (ligand) superfamily member 11 production
E0004896molecular_functioncytokine receptor activity
E0060333biological_processtype II interferon-mediated signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CL A 501
ChainResidue
AASN83
AASN85
ALYS88
DASN83
DASN85
DLYS88

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues454
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLU1-GLY228
EGLU1-GLY228

site_idSWS_FT_FI2
Number of Residues10
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN17
EASN223
BASN62
BASN69
BASN162
BASN223
EASN17
EASN62
EASN69
EASN162

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; in dimeric form => ECO:0000269|PubMed:6427223
ChainResidueDetails
AASN297
DASN297

222415

PDB entries from 2024-07-10

PDB statisticsPDBj update infoContact PDBjnumon