1FYH

1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001774	biological_process	microglial cell activation
A	0001819	biological_process	positive regulation of cytokine production
A	0002250	biological_process	adaptive immune response
A	0002281	biological_process	macrophage activation involved in immune response
A	0005125	molecular_function	cytokine activity
A	0005133	molecular_function	type II interferon receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006915	biological_process	apoptotic process
A	0006955	biological_process	immune response
A	0006959	biological_process	humoral immune response
A	0007166	biological_process	cell surface receptor signaling pathway
A	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009615	biological_process	response to virus
A	0010508	biological_process	positive regulation of autophagy
A	0010628	biological_process	positive regulation of gene expression
A	0010629	biological_process	negative regulation of gene expression
A	0010634	biological_process	positive regulation of epithelial cell migration
A	0030225	biological_process	macrophage differentiation
A	0030857	biological_process	negative regulation of epithelial cell differentiation
A	0032700	biological_process	negative regulation of interleukin-17 production
A	0032722	biological_process	positive regulation of chemokine production
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0032735	biological_process	positive regulation of interleukin-12 production
A	0032747	biological_process	positive regulation of interleukin-23 production
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0032834	biological_process	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
A	0033141	biological_process	positive regulation of peptidyl-serine phosphorylation of STAT protein
A	0034393	biological_process	positive regulation of smooth muscle cell apoptotic process
A	0038096	biological_process	Fc-gamma receptor signaling pathway involved in phagocytosis
A	0038196	biological_process	type III interferon-mediated signaling pathway
A	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
A	0045348	biological_process	positive regulation of MHC class II biosynthetic process
A	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
A	0045672	biological_process	positive regulation of osteoclast differentiation
A	0045785	biological_process	positive regulation of cell adhesion
A	0045821	biological_process	positive regulation of glycolytic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048143	biological_process	astrocyte activation
A	0048662	biological_process	negative regulation of smooth muscle cell proliferation
A	0050729	biological_process	positive regulation of inflammatory response
A	0050766	biological_process	positive regulation of phagocytosis
A	0050769	biological_process	positive regulation of neurogenesis
A	0050796	biological_process	regulation of insulin secretion
A	0051044	biological_process	positive regulation of membrane protein ectodomain proteolysis
A	0051607	biological_process	defense response to virus
A	0060333	biological_process	type II interferon-mediated signaling pathway
A	0060552	biological_process	positive regulation of fructose 1,6-bisphosphate metabolic process
A	0060557	biological_process	positive regulation of vitamin D biosynthetic process
A	0097191	biological_process	extrinsic apoptotic signaling pathway
A	0097696	biological_process	cell surface receptor signaling pathway via STAT
A	0098586	biological_process	cellular response to virus
A	0150076	biological_process	neuroinflammatory response
A	1900222	biological_process	negative regulation of amyloid-beta clearance
A	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
A	1901857	biological_process	positive regulation of cellular respiration
A	1902004	biological_process	positive regulation of amyloid-beta formation
A	1903078	biological_process	positive regulation of protein localization to plasma membrane
A	1903543	biological_process	positive regulation of exosomal secretion
A	1904440	biological_process	positive regulation of iron ion import across plasma membrane
A	2000309	biological_process	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
B	0004896	molecular_function	cytokine receptor activity
B	0060333	biological_process	type II interferon-mediated signaling pathway
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0001774	biological_process	microglial cell activation
D	0001819	biological_process	positive regulation of cytokine production
D	0002250	biological_process	adaptive immune response
D	0002281	biological_process	macrophage activation involved in immune response
D	0005125	molecular_function	cytokine activity
D	0005133	molecular_function	type II interferon receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006915	biological_process	apoptotic process
D	0006955	biological_process	immune response
D	0006959	biological_process	humoral immune response
D	0007166	biological_process	cell surface receptor signaling pathway
D	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
D	0008284	biological_process	positive regulation of cell population proliferation
D	0009615	biological_process	response to virus
D	0010508	biological_process	positive regulation of autophagy
D	0010628	biological_process	positive regulation of gene expression
D	0010629	biological_process	negative regulation of gene expression
D	0010634	biological_process	positive regulation of epithelial cell migration
D	0030225	biological_process	macrophage differentiation
D	0030857	biological_process	negative regulation of epithelial cell differentiation
D	0032700	biological_process	negative regulation of interleukin-17 production
D	0032722	biological_process	positive regulation of chemokine production
D	0032731	biological_process	positive regulation of interleukin-1 beta production
D	0032735	biological_process	positive regulation of interleukin-12 production
D	0032747	biological_process	positive regulation of interleukin-23 production
D	0032755	biological_process	positive regulation of interleukin-6 production
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0032834	biological_process	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
D	0033141	biological_process	positive regulation of peptidyl-serine phosphorylation of STAT protein
D	0034393	biological_process	positive regulation of smooth muscle cell apoptotic process
D	0038096	biological_process	Fc-gamma receptor signaling pathway involved in phagocytosis
D	0038196	biological_process	type III interferon-mediated signaling pathway
D	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
D	0045348	biological_process	positive regulation of MHC class II biosynthetic process
D	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
D	0045672	biological_process	positive regulation of osteoclast differentiation
D	0045785	biological_process	positive regulation of cell adhesion
D	0045821	biological_process	positive regulation of glycolytic process
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0048143	biological_process	astrocyte activation
D	0048662	biological_process	negative regulation of smooth muscle cell proliferation
D	0050729	biological_process	positive regulation of inflammatory response
D	0050766	biological_process	positive regulation of phagocytosis
D	0050769	biological_process	positive regulation of neurogenesis
D	0050796	biological_process	regulation of insulin secretion
D	0051044	biological_process	positive regulation of membrane protein ectodomain proteolysis
D	0051607	biological_process	defense response to virus
D	0060333	biological_process	type II interferon-mediated signaling pathway
D	0060552	biological_process	positive regulation of fructose 1,6-bisphosphate metabolic process
D	0060557	biological_process	positive regulation of vitamin D biosynthetic process
D	0097191	biological_process	extrinsic apoptotic signaling pathway
D	0097696	biological_process	cell surface receptor signaling pathway via STAT
D	0098586	biological_process	cellular response to virus
D	0150076	biological_process	neuroinflammatory response
D	1900222	biological_process	negative regulation of amyloid-beta clearance
D	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
D	1901857	biological_process	positive regulation of cellular respiration
D	1902004	biological_process	positive regulation of amyloid-beta formation
D	1903078	biological_process	positive regulation of protein localization to plasma membrane
D	1903543	biological_process	positive regulation of exosomal secretion
D	1904440	biological_process	positive regulation of iron ion import across plasma membrane
D	2000309	biological_process	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
E	0004896	molecular_function	cytokine receptor activity
E	0060333	biological_process	type II interferon-mediated signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 501

Chain	Residue
A	ASN83
A	ASN85
A	LYS88
D	ASN83
D	ASN85
D	LYS88

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"3109913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6427223","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"6427223","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; in dimeric form","evidences":[{"source":"PubMed","id":"6427223","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---