3E32
Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 2
Summary for 3E32
Entry DOI | 10.2210/pdb3e32/pdb |
Related | 1D8D 1KZO 1KZP 1SA4 1SA5 2IEJ 3E30 3E33 3E34 3E37 |
Descriptor | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, ZINC ION, ... (6 entities in total) |
Functional Keywords | ftase, farnesyltransferase, protein farnesyltransferase, malaria, antimalarial, ethylenediamine, inhibitor, plasmodium, falciparum, prenyltransferase, transferase, metal-binding, phosphoprotein, zinc |
Biological source | Rattus norvegicus (rat) More |
Total number of polymer chains | 2 |
Total formula weight | 93757.75 |
Authors | Hast, M.A.,Beese, L.S. (deposition date: 2008-08-06, release date: 2009-03-10, Last modification date: 2024-02-21) |
Primary citation | Hast, M.A.,Fletcher, S.,Cummings, C.G.,Pusateri, E.E.,Blaskovich, M.A.,Rivas, K.,Gelb, M.H.,Van Voorhis, W.C.,Sebti, S.M.,Hamilton, A.D.,Beese, L.S. Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem.Biol., 16:181-192, 2009 Cited by PubMed: 19246009DOI: 10.1016/j.chembiol.2009.01.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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