2IEJ
Human Protein Farnesyltransferase Complexed with Inhibitor Compound STN-48 And FPP Analog at 1.8A Resolution
Summary for 2IEJ
Entry DOI | 10.2210/pdb2iej/pdb |
Related PRD ID | PRD_900003 |
Descriptor | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase subunit beta, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | ftase, farnesyltransferase, farnesyl transferase, caax, ras, cancer, tumor regression, stn-48, protein prenylation, lipid modification, plasmodium, falciparum, malaria, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 95284.20 |
Authors | Hast, M.A.,Beese, L.S. (deposition date: 2006-09-19, release date: 2007-01-23, Last modification date: 2024-02-21) |
Primary citation | Eastman, R.T.,White, J.,Hucke, O.,Yokoyama, K.,Verlinde, C.L.,Hast, M.A.,Beese, L.S.,Gelb, M.H.,Rathod, P.K.,Van Voorhis, W.C. Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Mol.Biochem.Parasitol., 152:66-71, 2007 Cited by PubMed: 17208314DOI: 10.1016/j.molbiopara.2006.11.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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