2IEJ
Human Protein Farnesyltransferase Complexed with Inhibitor Compound STN-48 And FPP Analog at 1.8A Resolution
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | polymer | 382 | 44864.8 | 1 | UniProt (P49354) Pfam (PF01239) In PDB | Homo sapiens (human) | CAAX farnesyltransferase alpha subunit, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase alpha subunit, GGTase-I-alpha |
2 | B | Protein farnesyltransferase subunit beta | polymer | 437 | 48822.4 | 1 | UniProt (P49356) Pfam (PF00432) In PDB | Homo sapiens (human) | CAAX farnesyltransferase subunit beta, RAS proteins prenyltransferase beta, FTase-beta |
3 | C | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900003) | sucrose | ||
4 | A, B | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
5 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
6 | B | METHYL N-{(3S)-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-6-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-3-YL}-N-[(1-METHYL-1H-IMIDAZOL-4-YL)SULFONYL]GLYCINATE | non-polymer | 534.6 | 1 | Chemie (S48) | |||
7 | B | [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID | non-polymer | 359.4 | 1 | Chemie (FII) | |||
8 | water | water | 18.0 | 708 | Chemie (HOH) |
Sequence modifications
A: 1 - 379 (UniProt: P49354)
PDB | External Database | Details |
---|---|---|
Glu 380 | - | cloning artifact |
Glu 381 | - | cloning artifact |
Phe 382 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 93687.2 | |
Branched | Number of molecules | 1 |
Total formula weight | 342.3 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1254.7 | |
All* | Total formula weight | 95284.2 |