2IEJ

Human Protein Farnesyltransferase Complexed with Inhibitor Compound STN-48 And FPP Analog at 1.8A Resolution

Summary for 2IEJ

Entry DOI	10.2210/pdb2iej/pdb
Related PRD ID	PRD_900003
Descriptor	Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase subunit beta, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (8 entities in total)
Functional Keywords	ftase, farnesyltransferase, farnesyl transferase, caax, ras, cancer, tumor regression, stn-48, protein prenylation, lipid modification, plasmodium, falciparum, malaria, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	95284.20
Authors	Hast, M.A.,Beese, L.S. (deposition date: 2006-09-19, release date: 2007-01-23, Last modification date: 2024-02-21)
Primary citation	Eastman, R.T.,White, J.,Hucke, O.,Yokoyama, K.,Verlinde, C.L.,Hast, M.A.,Beese, L.S.,Gelb, M.H.,Rathod, P.K.,Van Voorhis, W.C. Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Mol.Biochem.Parasitol., 152:66-71, 2007 Cited by PubMed: 17208314 DOI: 10.1016/j.molbiopara.2006.11.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation