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8TKC
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BU of 8tkc by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-b.01 FAB
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ...
著者Pletnev, S, Hoyt, F, Fischer, E, Kwong, P.
登録日2023-07-25
公開日2024-08-28
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques.
To Be Published
8TL4
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BU of 8tl4 by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-e.01 FAB
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ...
著者Pletnev, S, Hoyt, F, Fischer, E, Kwong, P.
登録日2023-07-26
公開日2024-08-28
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques.
To Be Published
8TY1
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BU of 8ty1 by Molmil
Cryo-EM structure of coagulation factor VIII bound to NB2E9
分子名称: Coagulation factor VIII, NB2E9 heavy chain, NB2E9 light chain, ...
著者Childers, K.C, Spiegel, P.C.
登録日2023-08-24
公開日2023-09-13
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Structural basis for inhibition of coagulation factor VIII reveals a shared immunogenic hot-spot on the C1 domain
To Be Published
8UCD
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BU of 8ucd by Molmil
Cryo-EM structure of human STEAP1 in complex with AMG 509 Fab
分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, AMG 509 anti-STEAP1 Fab, heavy chain, ...
著者Li, F, Bailis, J.M, Zhang, H.
登録日2023-09-26
公開日2023-11-22
最終更新日2024-01-24
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer.
Cancer Discov, 14, 2024
8TUI
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BU of 8tui by Molmil
Crystal structure of Fab-Lirilumab bound to KIR2DL3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Killer cell immunoglobulin-like receptor 2DL3, Lirilumab Fab Heavy Chain, ...
著者Lorig-Roach, N, DuBois, R.M.
登録日2023-08-16
公開日2023-12-06
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural basis for the activity and specificity of the immune checkpoint inhibitor lirilumab.
Sci Rep, 14, 2024
8U4R
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BU of 8u4r by Molmil
Structure of REGN7663-Fab bound CXCR4
分子名称: C-X-C chemokine receptor type 4, CHOLESTEROL, REGN7663 Fab heavy chain, ...
著者Saotome, K, McGoldrick, L.L, Franklin, M.C.
登録日2023-09-11
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into CXCR4 modulation and oligomerization
Biorxiv, 2024
8UTA
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BU of 8uta by Molmil
yjdF riboswitch from R. gauvreauii in complex with proflavine bound to Fab BL3-6 S97N
分子名称: Fab BL3-6 S97N heavy chain, Fab BL3-6 S97N light chain, MAGNESIUM ION, ...
著者Krochmal, D, Lewicka, A, Piccirilli, J.A.
登録日2023-10-30
公開日2024-04-10
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Structural basis for promiscuity in ligand recognition by yjdF riboswitch.
Cell Discov, 10, 2024
8U4T
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BU of 8u4t by Molmil
Structure of tetrameric CXCR4 in complex with REGN7663 Fab
分子名称: (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, C-X-C chemokine receptor type 4, CHOLESTEROL, ...
著者Saotome, K, McGoldrick, L.L, Franklin, M.C.
登録日2023-09-11
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Structural insights into CXCR4 modulation and oligomerization
Biorxiv, 2024
8UIW
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BU of 8uiw by Molmil
yjdF riboswitch from R. gauvreauii in complex with chelerythrine bound to Fab BL3-6 S97N
分子名称: 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium, Fab BL3-6 S97N heavy chain, Fab BL3-6 S97N light chain, ...
著者Krochmal, D, Lewicka, A, Piccirilli, J.A.
登録日2023-10-10
公開日2024-04-10
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Structural basis for promiscuity in ligand recognition by yjdF riboswitch.
Cell Discov, 10, 2024
8U4S
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BU of 8u4s by Molmil
Structure of trimeric CXCR4 in complex with REGN7663 Fab
分子名称: (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, C-X-C chemokine receptor type 4, CHOLESTEROL, ...
著者Saotome, K, McGoldrick, L.L, Franklin, M.C.
登録日2023-09-11
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structural insights into CXCR4 modulation and oligomerization
Biorxiv, 2024
8U4Q
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BU of 8u4q by Molmil
Structure of REGN7663 Fab-bound CXCR4/Gi complex
分子名称: C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Saotome, K, McGoldrick, L.L, Franklin, M.C.
登録日2023-09-11
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Structural insights into CXCR4 modulation and oligomerization
Biorxiv, 2024
8TZU
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BU of 8tzu by Molmil
OC43 S1b domain in complex with WNb 293 and WNb 317
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Pymm, P, Feng, J, Tham, W.H.
登録日2023-08-27
公開日2024-05-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献OC43 S1b domain in complex with WNb 293 and WNb 317
To Be Published
6VL5
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BU of 6vl5 by Molmil
BG505 SOSIP reconstructed from a designed tetrahedral nanoparticle, BG505 SOSIP-T33_dn2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP.v5.2(7S) - gp120, ...
著者Ward, A.B, Antanasijevic, A.
登録日2020-01-22
公開日2020-08-12
最終更新日2020-09-02
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations.
NPJ Vaccines, 5, 2020
6VL6
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BU of 6vl6 by Molmil
De novo designed tetrahedral nanoparticle T33_dn2 presenting BG505 SOSIP trimers
分子名称: T33_dn2A, T33_dn2B
著者Ward, A.B, Antanasijevic, A.
登録日2020-01-22
公開日2020-08-12
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations.
NPJ Vaccines, 5, 2020
6VXW
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BU of 6vxw by Molmil
NMR solution structure of natural scorpion toxin Cl13
分子名称: Beta-toxin Cl13
著者del Rio Portilla, F, Delepierre, M, Lopez Giraldo, A.E.
登録日2020-02-24
公開日2020-07-08
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献The three-dimensional structure of the toxic peptide Cl13 from the scorpion Centruroides limpidus.
Toxicon, 184, 2020
6VXF
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BU of 6vxf by Molmil
Structure of apo-closed ABCG2
分子名称: Broad substrate specificity ATP-binding cassette transporter ABCG2
著者Orlando, B.J, Maofu, L.
登録日2020-02-21
公開日2020-05-13
最終更新日2020-05-20
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献ABCG2 transports anticancer drugs via a closed-to-open switch.
Nat Commun, 11, 2020
6VXI
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BU of 6vxi by Molmil
Structure of ABCG2 bound to mitoxantrone
分子名称: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL
著者Orlando, B.J, Liao, M.
登録日2020-02-21
公開日2020-05-13
最終更新日2020-05-20
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献ABCG2 transports anticancer drugs via a closed-to-open switch.
Nat Commun, 11, 2020
6VXH
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BU of 6vxh by Molmil
Structure of ABCG2 bound to imatinib
分子名称: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL
著者Orlando, B.J, Liao, M.
登録日2020-02-21
公開日2020-05-13
最終更新日2020-05-20
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献ABCG2 transports anticancer drugs via a closed-to-open switch.
Nat Commun, 11, 2020
8TTM
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BU of 8ttm by Molmil
IgG1 Fc Heterodimer combYSelect1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain
著者Azzam, T, Du, J.J, Sundberg, E.J.
登録日2023-08-14
公開日2024-06-26
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.
Sci Adv, 10, 2024
6W4V
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BU of 6w4v by Molmil
Structure of anti-ferroportin Fab45D8
分子名称: 1,2-ETHANEDIOL, Fab45D8 Heavy Chain, Fab45D8 Light Chain
著者Billesboelle, C.B, Azumaya, C.M, Gonen, S, Powers, A, Kretsch, R.C, Schneider, S, Arvedson, T, Dror, R.O, Cheng, Y, Manglik, A.
登録日2020-03-11
公開日2020-09-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.
Nature, 586, 2020
8TUD
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BU of 8tud by Molmil
IgG1 Fc Heterodimer combYSelect2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain
著者Azzam, T, Du, J.J, Sundberg, E.J.
登録日2023-08-16
公開日2024-06-26
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.
Sci Adv, 10, 2024
6X3V
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BU of 6x3v by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Etomidate, ...
著者Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
登録日2020-05-21
公開日2020-09-09
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
6VXJ
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BU of 6vxj by Molmil
Structure of ABCG2 bound to SN38
分子名称: 7-ethyl-10-hydroxycamptothecin, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL
著者Orlando, B.J, Liao, M.
登録日2020-02-22
公開日2020-05-13
最終更新日2020-05-20
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献ABCG2 transports anticancer drugs via a closed-to-open switch.
Nat Commun, 11, 2020
8U44
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BU of 8u44 by Molmil
CryoEM structure of A/Solomon Islands/3/2006 H1 HA in complex with 05.GC.w2.3C10-H1_SI06
分子名称: 05.GC.w2.3C10-H1_SI06 Heavy chain, 05.GC.w2.3C10-H1_SI06 Light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Moore, N, Han, J, Ward, A.B, Wilson, I.A.
登録日2023-09-08
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Persistence of germinal center B cell responses after influenza virus vaccination in humans
To Be Published
6WW2
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BU of 6ww2 by Molmil
Structure of human Frizzled5 by fiducial-assisted cryo-EM
分子名称: Frizzled-5,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ...
著者Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C.
登録日2020-05-07
公開日2020-08-19
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
Elife, 9, 2020

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件を2024-09-04に公開中

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