8TUD

IgG1 Fc Heterodimer combYSelect2

Summary for 8TUD

• Entry DOI: 10.2210/pdb8tud/pdb
• Descriptor: Immunoglobulin gamma-1 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: igg1 fc, heterodimer, immune system
• Biological source: Homo sapiens x Mus musculus hybrid cell line; More
• Total number of polymer chains: 2
• Total formula weight: 55205.82

Authors

Azzam, T.,Du, J.J.,Sundberg, E.J. (deposition date: 2023-08-16, release date: 2024-06-26)

• Primary citation: Azzam, T.,Du, J.J.,Flowers, M.W.,Ali, A.V.,Hunn, J.C.,Vijayvargiya, N.,Knagaram, R.,Bogacz, M.,Maravillas, K.E.,Sastre, D.E.,Fields, J.K.,Mirzaei, A.,Pierce, B.G.,Sundberg, E.J.; Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.; Sci Adv, 10:eadk8157-eadk8157, 2024; PubMed: 38598628; DOI: 10.1126/sciadv.adk8157

Experimental method

X-RAY DIFFRACTION (3 Å)