6VXJ

Structure of ABCG2 bound to SN38

Summary for 6VXJ

Entry DOI	10.2210/pdb6vxj/pdb
EMDB information	21436 21437 21438 21439 21440 21441
Descriptor	Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, 7-ethyl-10-hydroxycamptothecin (3 entities in total)
Functional Keywords	abcg2, sn38, abc transporter, nanodisc, translocase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	145937.42
Authors	Orlando, B.J.,Liao, M. (deposition date: 2020-02-22, release date: 2020-05-13, Last modification date: 2020-05-20)
Primary citation	Orlando, B.J.,Liao, M. ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11:2264-2264, 2020 Cited by PubMed: 32385283 DOI: 10.1038/s41467-020-16155-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.1 Å)

Structure validation