6X3V

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate

Summary for 6X3V

Entry DOI	10.2210/pdb6x3v/pdb
EMDB information	22034
Descriptor	Gamma-aminobutyric acid receptor subunit beta-2, GAMMA-AMINO-BUTANOIC ACID, Etomidate, ... (11 entities in total)
Functional Keywords	ion channel, cys-loop receptor, pentametic ligand gated channel, gabaa receptor, membrane protein
Biological source	Homo sapiens More
Total number of polymer chains	9
Total formula weight	365092.46
Authors	Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh, R.M.,Lindahl, E.,Hibbs, R.E. (deposition date: 2020-05-21, release date: 2020-09-09, Last modification date: 2024-01-31)
Primary citation	Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh Jr., R.M.,Lindahl, E.,Hibbs, R.E. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585:303-308, 2020 Cited by PubMed: 32879488 DOI: 10.1038/s41586-020-2654-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation