6X3V

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0004890	molecular_function	GABA-A receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0004890	molecular_function	GABA-A receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0004890	molecular_function	GABA-A receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0004890	molecular_function	GABA-A receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0004890	molecular_function	GABA-A receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0006821	biological_process	chloride transport
E	0007214	biological_process	gamma-aminobutyric acid signaling pathway
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CqLqLhnFPmDehsC

Chain	Residue	Details
E	CYS151-CYS165
B	CYS139-CYS153
A	CYS136-CYS150

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
I	TYR191-HIS197
J	PHE430-HIS436

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	233
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
E	ALA11-CYS244
D	GLN1-GLY224

---

site_id	SWS_FT_FI2
Number of Residues	88
Details	TRANSMEM: Helical => ECO:0000305

Chain	Residue	Details
E	TYR235-ILE257
E	ALA261-ALA283
E	ALA295-LEU317
E	TYR334-TYR356
D	TYR225-TRP246
D	VAL252-ALA273
D	MET286-VAL307
D	LEU324-LEU345

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN13
E	ASN90
E	ASN208
C	ASN8
C	ASN80
C	ASN149

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN11
B	ASN111
D	ASN11
D	ASN111

---