6VXH
Structure of ABCG2 bound to imatinib
Summary for 6VXH
| Entry DOI | 10.2210/pdb6vxh/pdb |
| EMDB information | 21436 21437 21438 21439 21440 21441 |
| Descriptor | Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE (3 entities in total) |
| Functional Keywords | abcg2, abc transporter, imatinib, translocase-translocase inhibitor complex, translocase/translocase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 146038.61 |
| Authors | Orlando, B.J.,Liao, M. (deposition date: 2020-02-21, release date: 2020-05-13, Last modification date: 2020-05-20) |
| Primary citation | Orlando, B.J.,Liao, M. ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11:2264-2264, 2020 Cited by PubMed: 32385283DOI: 10.1038/s41467-020-16155-2 PDB entries with the same primary citation |
| Experimental method |
Structure validation
Download full validation report
