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6VXH

Structure of ABCG2 bound to imatinib

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Broad substrate specificity ATP-binding cassette transporter ABCG2polymer65572385.92UniProt (Q9UNQ0)
Pfam (PF00005)
Pfam (PF19055)
Pfam (PF01061)
Homo sapiens (Human)ATP-binding cassette sub-family G member 2,Breast cancer resistance protein,CDw338,Mitoxantrone resistance-associated protein,Placenta-specific ATP-binding cassette transporter,Urate exporter
2C, E
(A, B)
CHOLESTEROLnon-polymer386.72Chemie (CLR)
3D
(B)
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDEnon-polymer493.61Chemie (STI)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight144771.7
Non-Polymers*Number of molecules3
Total formula weight1266.9
All*Total formula weight146038.6
*Water molecules are not included.

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PDB entries from 2026-01-28

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