6XBK
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![BU of 6xbk by Molmil](/molmil-images/mine/6xbk) | Structure of human SMO-G111C/I496C complex with Gi | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Qi, X, Long, T, Li, X. | 登録日 | 2020-06-06 | 公開日 | 2020-09-30 | 最終更新日 | 2020-11-25 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020
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6XBJ
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![BU of 6xbj by Molmil](/molmil-images/mine/6xbj) | Structure of human SMO-D384R complex with Gi | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Qi, X, Long, T, Li, X. | 登録日 | 2020-06-06 | 公開日 | 2020-09-30 | 最終更新日 | 2020-11-25 | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | 主引用文献 | Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020
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6X1A
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![BU of 6x1a by Molmil](/molmil-images/mine/6x1a) | Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor | 分子名称: | 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Belousoff, M.J, Zhang, X, Danev, R. | 登録日 | 2020-05-18 | 公開日 | 2020-09-09 | 最終更新日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol.Cell, 80, 2020
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6X19
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![BU of 6x19 by Molmil](/molmil-images/mine/6x19) | Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor | 分子名称: | 3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Belousoff, M.J, Zhang, X, Danev, R. | 登録日 | 2020-05-18 | 公開日 | 2020-09-09 | 最終更新日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | 主引用文献 | Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol.Cell, 80, 2020
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6X18
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![BU of 6x18 by Molmil](/molmil-images/mine/6x18) | GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor | 分子名称: | Glucagon, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Belousoff, M.J, Zhang, X, Danev, R. | 登録日 | 2020-05-18 | 公開日 | 2020-09-09 | 最終更新日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | 主引用文献 | Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol.Cell, 80, 2020
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6WZG
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![BU of 6wzg by Molmil](/molmil-images/mine/6wzg) | Human secretin receptor Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Piper, S.J, Belousoff, M.J, Danev, R. | 登録日 | 2020-05-13 | 公開日 | 2020-08-12 | 最終更新日 | 2020-09-02 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Structure and dynamics of the active Gs-coupled human secretin receptor. Nat Commun, 11, 2020
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6WWZ
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![BU of 6wwz by Molmil](/molmil-images/mine/6wwz) | Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein | 分子名称: | C-C chemokine receptor type 6,C-C chemokine receptor type 6, C-C motif chemokine 20, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wasilko, D.J, Johnson, Z.L, Ammirati, M, Han, S, Wu, H. | 登録日 | 2020-05-09 | 公開日 | 2020-06-24 | 最終更新日 | 2020-07-01 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20. Nat Commun, 11, 2020
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6WPW
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![BU of 6wpw by Molmil](/molmil-images/mine/6wpw) | GCGR-Gs signaling complex bound to a designed glucagon derivative | 分子名称: | Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hilger, D, Krishna Kumar, K, Hu, H, Mathiesen, J.M, Skiniotis, G, Kobilka, B.K. | 登録日 | 2020-04-28 | 公開日 | 2020-08-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into differences in G protein activation by family A and family B GPCRs. Science, 369, 2020
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6WI9
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![BU of 6wi9 by Molmil](/molmil-images/mine/6wi9) | Human secretin receptor Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Belousoff, M.J, Khoshouei, M. | 登録日 | 2020-04-09 | 公開日 | 2020-08-12 | 最終更新日 | 2020-09-02 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structure and dynamics of the active Gs-coupled human secretin receptor. Nat Commun, 11, 2020
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6WHC
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![BU of 6whc by Molmil](/molmil-images/mine/6whc) | CryoEM Structure of the glucagon receptor with a dual-agonist peptide | 分子名称: | Dual-agonist peptide, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Belousoff, M.J, Sexton, P, Danev, R. | 登録日 | 2020-04-07 | 公開日 | 2020-05-27 | 最終更新日 | 2020-07-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide. J.Biol.Chem., 295, 2020
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6WHA
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![BU of 6wha by Molmil](/molmil-images/mine/6wha) | HTR2A bound to 25-CN-NBOH in complex with a mini-Galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) | 分子名称: | 4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile, G subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Skiniotis, G, Roth, B, Kim, K, Panova, O. | 登録日 | 2020-04-07 | 公開日 | 2020-09-23 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor Cell(Cambridge,Mass.), 182, 2020
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6VN7
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![BU of 6vn7 by Molmil](/molmil-images/mine/6vn7) | Cryo-EM structure of an activated VIP1 receptor-G protein complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Duan, J, Shen, D.-D, Zhou, X.E, Liu, Q.-F, Zhuang, Y.-W, Zhang, H.-B, Xu, P.-Y, Ma, S.-S, He, X.-H, Melcher, K, Zhang, Y, Xu, H.E, Yi, J. | 登録日 | 2020-01-29 | 公開日 | 2020-09-02 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nat Commun, 11, 2020
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6VMS
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![BU of 6vms by Molmil](/molmil-images/mine/6vms) | Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane | 分子名称: | Endolysin,D(2) dopamine receptor,D(2) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yin, J, Chen, K.M, Clark, M.J, Hijazi, M, Kumari, P, Bai, X, Sunahara, R.K, Barth, P, Rosenbaum, D.M. | 登録日 | 2020-01-28 | 公開日 | 2020-06-17 | 最終更新日 | 2020-08-19 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane. Nature, 584, 2020
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6VCB
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![BU of 6vcb by Molmil](/molmil-images/mine/6vcb) | Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator | 分子名称: | 1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole, Glucagon-like peptide 1, Glucagon-like peptide 1 receptor, ... | 著者 | Sun, B, Feng, D, Bueno, A, Kobilka, B, Sloop, K. | 登録日 | 2019-12-20 | 公開日 | 2020-07-22 | 最終更新日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into probe-dependent positive allosterism of the GLP-1 receptor. Nat.Chem.Biol., 16, 2020
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6UVA
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![BU of 6uva by Molmil](/molmil-images/mine/6uva) | CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin 2 peptide | 分子名称: | Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. | 登録日 | 2019-11-01 | 公開日 | 2020-04-01 | 最終更新日 | 2020-04-29 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
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6UUS
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![BU of 6uus by Molmil](/molmil-images/mine/6uus) | CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin peptide | 分子名称: | ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. | 登録日 | 2019-10-31 | 公開日 | 2020-04-01 | 最終更新日 | 2020-04-29 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
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6UUN
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![BU of 6uun by Molmil](/molmil-images/mine/6uun) | CryoEM Structure of the active Adrenomedullin 1 receptor G protein complex with adrenomedullin peptide | 分子名称: | ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. | 登録日 | 2019-10-30 | 公開日 | 2020-03-25 | 最終更新日 | 2020-04-29 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
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6U7C
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![BU of 6u7c by Molmil](/molmil-images/mine/6u7c) | Human GRK2 in complex with Gbetagamma subunits and CCG258747 | 分子名称: | 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(2H-indazol-3-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Bouley, R, Tesmer, J.J.G. | 登録日 | 2019-09-02 | 公開日 | 2020-04-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of themu-Opioid Receptor. Mol.Pharmacol., 97, 2020
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6RMV
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![BU of 6rmv by Molmil](/molmil-images/mine/6rmv) | The crystal structure of a TRP channel peptide bound to a G protein beta gamma heterodimer | 分子名称: | GLYCEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Gruss, F, Oberwinkler, J, Ulens, C. | 登録日 | 2019-05-07 | 公開日 | 2020-10-14 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | The structural basis for an on-off switch controlling G beta gamma-mediated inhibition of TRPM3 channels. Proc.Natl.Acad.Sci.USA, 117, 2020
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6QNO
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![BU of 6qno by Molmil](/molmil-images/mine/6qno) | Rhodopsin-Gi protein complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab antibody fragment heavy chain, Fab antibody fragment light chain, ... | 著者 | Tsai, C.-J, Marino, J, Adaixo, R.J, Pamula, F, Muehle, J, Maeda, S, Flock, T, Taylor, N.M.I, Mohammed, I, Matile, H, Dawson, R.J.P, Deupi, X, Stahlberg, H, Schertler, G.F.X. | 登録日 | 2019-02-11 | 公開日 | 2019-07-10 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.38 Å) | 主引用文献 | Cryo-EM structure of the rhodopsin-G alpha i-beta gamma complex reveals binding of the rhodopsin C-terminal tail to the G beta subunit. Elife, 8, 2019
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6PT0
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![BU of 6pt0 by Molmil](/molmil-images/mine/6pt0) | Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2 | 分子名称: | CHOLESTEROL, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, T.H, Xing, C, Zhuang, Y, Feng, Z, Zhou, X.E, Chen, M, Wang, L, Meng, X, Xue, Y, Wang, J, Liu, H, McGuire, T, Zhao, G, Melcher, K, Zhang, C, Xu, H.E, Xie, X.Q. | 登録日 | 2019-07-14 | 公開日 | 2020-02-12 | 最終更新日 | 2020-03-04 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM Structure of the Human Cannabinoid Receptor CB2-GiSignaling Complex. Cell, 180, 2020
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6PCV
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![BU of 6pcv by Molmil](/molmil-images/mine/6pcv) | Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 | 著者 | Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G. | 登録日 | 2019-06-18 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold. Sci Adv, 5, 2019
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6PB1
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![BU of 6pb1 by Molmil](/molmil-images/mine/6pb1) | Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 2 receptor in complex with Gs protein and Nb35 | 分子名称: | CHOLESTEROL, Corticotropin-releasing factor receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ma, S, Shen, Q, Zhao, L.-H, Mao, C, Zhou, X.E, Shen, D.-D, de Waal, P.W, Bi, P, Li, C, Jiang, Y, Wang, M.-W, Sexton, P.M, Wootten, D, Melcher, K, Zhang, Y, Xu, H.E. | 登録日 | 2019-06-12 | 公開日 | 2020-02-12 | 最終更新日 | 2020-02-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors. Mol.Cell, 77, 2020
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6PB0
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![BU of 6pb0 by Molmil](/molmil-images/mine/6pb0) | Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 1 receptor in complex with Gs protein and Nb35 | 分子名称: | CHOLESTEROL, Corticotropin-releasing factor receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ma, S, Shen, Q, Zhao, L.-H, Mao, C, Zhou, X.E, Shen, D.-D, de Waal, P.W, Bi, P, Li, C, Jiang, Y, Wang, M.-W, Sexton, P.M, Wootten, D, Melcher, K, Zhang, Y, Xu, H.E. | 登録日 | 2019-06-12 | 公開日 | 2020-02-12 | 最終更新日 | 2020-02-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors. Mol.Cell, 77, 2020
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6P9Y
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![BU of 6p9y by Molmil](/molmil-images/mine/6p9y) | PAC1 GPCR Receptor complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. | 登録日 | 2019-06-10 | 公開日 | 2020-02-05 | 最終更新日 | 2020-02-19 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation. Mol.Cell, 77, 2020
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