7F58
| Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex | 分子名称: | (3R)-N-[(2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxidanylidene-propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. | 登録日 | 2021-06-21 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
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7F55
| Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex | 分子名称: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. | 登録日 | 2021-06-21 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
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7F54
| Cryo-EM structure of afamelanotide-MC4R-Gs_Nb35 complex | 分子名称: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. | 登録日 | 2021-06-21 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
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7F53
| Cryo-EM structure of a-MSH-MC4R-Gs_Nb35 complex | 分子名称: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. | 登録日 | 2021-06-21 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
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7F4I
| Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35 | 分子名称: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. | 登録日 | 2021-06-18 | 公開日 | 2021-09-08 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
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7F4H
| Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein, Nb35 and scFv16 | 分子名称: | Afamelanotide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. | 登録日 | 2021-06-18 | 公開日 | 2021-09-08 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
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7F4F
| Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein and scFv16 | 分子名称: | Afamelanotide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. | 登録日 | 2021-06-18 | 公開日 | 2021-09-08 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
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7F4D
| Cryo-EM structure of alpha-MSH-bound melanocortin-1 receptor in complex with Gs protein and Nb35 | 分子名称: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. | 登録日 | 2021-06-18 | 公開日 | 2021-09-08 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
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7F2O
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7F24
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7F23
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7F1Z
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7F1T
| Crystal structure of the human chemokine receptor CCR5 in complex with MIP-1a | 分子名称: | C-C motif chemokine 3,C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION | 著者 | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | 登録日 | 2021-06-09 | 公開日 | 2021-07-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
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7F1S
| Cryo-EM structure of the apo chemokine receptor CCR5 in complex with Gi | 分子名称: | C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | 登録日 | 2021-06-09 | 公開日 | 2021-07-14 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
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7F1R
| Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi | 分子名称: | C-C motif chemokine 5,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | 登録日 | 2021-06-09 | 公開日 | 2021-07-14 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
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7F1Q
| Cryo-EM structure of the chemokine receptor CCR5 in complex with MIP-1a and Gi | 分子名称: | C-C motif chemokine 3,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | 登録日 | 2021-06-09 | 公開日 | 2021-07-14 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
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7F1O
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7F0T
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7EZM
| Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gq complex | 分子名称: | Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y. | 登録日 | 2021-06-01 | 公開日 | 2021-08-25 | 最終更新日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor Nat.Chem.Biol., 17, 2021
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7EZK
| Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gs complex | 分子名称: | Chimera of Guanine nucleotide-binding protein G(i) subunit alpha-1 and Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Cholecystokinin receptor type A, Cholecystokinin-8, ... | 著者 | Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y. | 登録日 | 2021-06-01 | 公開日 | 2021-08-25 | 最終更新日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor Nat.Chem.Biol., 17, 2021
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7EZH
| Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex | 分子名称: | Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y. | 登録日 | 2021-06-01 | 公開日 | 2021-08-25 | 最終更新日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor Nat.Chem.Biol., 17, 2021
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7EZC
| Adenosine A2a receptor mutant-I92N | 分子名称: | 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, Adenosine receptor A2a,Soluble cytochrome b562 | 著者 | Cui, M, Zhou, Q, Yao, D, Zhao, S, Song, G. | 登録日 | 2021-06-01 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Crystal structure of a constitutive active mutant of adenosine A 2A receptor. Iucrj, 9, 2022
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7EXD
| Lasmiditan-bound serotonin 1F (5-HT1F) receptor-Gi protein complex | 分子名称: | 2,4,6-tris(fluoranyl)-N-[6-(1-methylpiperidin-4-yl)carbonylpyridin-2-yl]benzamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Huang, S, Xu, P, Jiang, Y, Xu, H.E. | 登録日 | 2021-05-27 | 公開日 | 2021-08-04 | 最終更新日 | 2021-10-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT 1F -G protein complex. Cell Res., 31, 2021
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7EW7
| Cryo-EM structure of SEW2871-bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein | 分子名称: | 5-[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jia, G.W, Yuan, Y, Su, Z.M, Shao, Z.H. | 登録日 | 2021-05-24 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021
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7EW4
| Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. | 登録日 | 2021-05-24 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
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