7F4H

Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein, Nb35 and scFv16

Summary for 7F4H

• Entry DOI: 10.2210/pdb7f4h/pdb
• EMDB information: 31448 31449 31452 31453
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-1, Nanobody 35, ... (8 entities in total)
• Functional Keywords: g protein-coupled receptors, mc1r, melanocyte, clacium ion, activation, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 7
• Total formula weight: 207502.07

Authors

Ma, S.,Chen, Y.,Dai, A.,Yin, W.,Guo, J.,Yang, D.,Zhou, F.,Jiang, Y.,Wang, M.-W.,Xu, H.E. (deposition date: 2021-06-18, release date: 2021-09-08, Last modification date: 2022-02-16)

• Primary citation: Ma, S.,Chen, Y.,Dai, A.,Yin, W.,Guo, J.,Yang, D.,Zhou, F.,Jiang, Y.,Wang, M.W.,Xu, H.E.; Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.; Cell Res., 31:1061-1071, 2021; PubMed: 34453129; DOI: 10.1038/s41422-021-00557-y

Experimental method

ELECTRON MICROSCOPY (2.7 Å)