7F4H
Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein, Nb35 and scFv16
Summary for 7F4H
Entry DOI | 10.2210/pdb7f4h/pdb |
EMDB information | 31448 31449 31452 31453 |
Descriptor | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-1, Nanobody 35, ... (8 entities in total) |
Functional Keywords | g protein-coupled receptors, mc1r, melanocyte, clacium ion, activation, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 7 |
Total formula weight | 207502.07 |
Authors | |
Primary citation | Ma, S.,Chen, Y.,Dai, A.,Yin, W.,Guo, J.,Yang, D.,Zhou, F.,Jiang, Y.,Wang, M.W.,Xu, H.E. Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31:1061-1071, 2021 Cited by PubMed: 34453129DOI: 10.1038/s41422-021-00557-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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