7EZM

Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gq complex

Summary for 7EZM

• Entry DOI: 10.2210/pdb7ezm/pdb
• Related: 7EZH 7EZK
• EMDB information: 31387 31388 31389
• Descriptor: fusion protein of Guanine nucleotide-binding protein G(i) subunit alpha-1 and Guanine nucleotide-binding protein G(q) subunit alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Cholecystokinin receptor type A, ... (6 entities in total)
• Functional Keywords: cholecystokinin a receptor, gq complex, cck-8, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 163329.21

Authors

Liu, Q.F.,Yang, D.H.,Zhuang, Y.W.,Croll, T.I.,Cai, X.Q.,Duan, J.,Dai, A.T.,Yin, W.C.,Ye, C.Y.,Zhou, F.L.,Wu, B.L.,Zhao, Q.,Xu, H.E.,Wang, M.W.,Jiang, Y. (deposition date: 2021-06-01, release date: 2021-08-25, Last modification date: 2022-06-29)

• Primary citation: Liu, Q.,Yang, D.,Zhuang, Y.,Croll, T.I.,Cai, X.,Dai, A.,He, X.,Duan, J.,Yin, W.,Ye, C.,Zhou, F.,Wu, B.,Zhao, Q.,Xu, H.E.,Wang, M.W.,Jiang, Y.; Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor; Nat.Chem.Biol., 17:1238-1244, 2021; DOI: 10.1038/s41589-021-00841-3

Experimental method

ELECTRON MICROSCOPY (2.9 Å)