7SRR
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![BU of 7srr by Molmil](/molmil-images/mine/7srr) | 5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM) | 分子名称: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2B, G protein subunit q (Gi2-mini-Gq chimera), ... | 著者 | Barros-Alvarez, X, Kim, K, Panova, O, Cao, C, Roth, B.L, Skiniotis, G. | 登録日 | 2021-11-08 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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7VVN
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![BU of 7vvn by Molmil](/molmil-images/mine/7vvn) | PTH-bound human PTH1R in complex with Gs (class4) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | 登録日 | 2021-11-06 | 公開日 | 2022-08-03 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82, 2022
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7VVK
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![BU of 7vvk by Molmil](/molmil-images/mine/7vvk) | PTH-bound human PTH1R in complex with Gs (class1) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | 登録日 | 2021-11-06 | 公開日 | 2022-08-03 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82, 2022
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7VVM
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![BU of 7vvm by Molmil](/molmil-images/mine/7vvm) | PTH-bound human PTH1R in complex with Gs (class3) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | 登録日 | 2021-11-06 | 公開日 | 2022-08-03 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82, 2022
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7VVJ
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![BU of 7vvj by Molmil](/molmil-images/mine/7vvj) | PTHrP-bound human PTH1R in complex with Gs | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | 登録日 | 2021-11-06 | 公開日 | 2022-08-03 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82, 2022
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7VVO
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![BU of 7vvo by Molmil](/molmil-images/mine/7vvo) | PTH-bound human PTH1R in complex with Gs (class5) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | 登録日 | 2021-11-06 | 公開日 | 2022-08-03 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82, 2022
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7VVL
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![BU of 7vvl by Molmil](/molmil-images/mine/7vvl) | PTH-bound human PTH1R in complex with Gs (class2) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | 登録日 | 2021-11-06 | 公開日 | 2022-08-03 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82, 2022
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7SQO
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![BU of 7sqo by Molmil](/molmil-images/mine/7sqo) | Structure of the orexin-2 receptor(OX2R) bound to TAK-925, Gi and scFv16 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | McGrath, A.P, Kang, Y, Flinspach, M. | 登録日 | 2021-11-05 | 公開日 | 2022-05-25 | 最終更新日 | 2022-07-06 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13, 2022
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7VUZ
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![BU of 7vuz by Molmil](/molmil-images/mine/7vuz) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2 | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VV5
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![BU of 7vv5 by Molmil](/molmil-images/mine/7vv5) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1 | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VUY
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![BU of 7vuy by Molmil](/molmil-images/mine/7vuy) | |
7VV3
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![BU of 7vv3 by Molmil](/molmil-images/mine/7vv3) | |
7VUH
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![BU of 7vuh by Molmil](/molmil-images/mine/7vuh) | Cryo-EM structure of a class A orphan GPCR | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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7VUJ
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![BU of 7vuj by Molmil](/molmil-images/mine/7vuj) | Cryo-EM structure of a class A orphan GPCR | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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7VUG
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![BU of 7vug by Molmil](/molmil-images/mine/7vug) | Cryo-EM structure of a class A orphan GPCR in complex with Gi | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Chimera of Endo-1,4-beta-xylanase and Probable G-protein coupled receptor 139, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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7VUI
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![BU of 7vui by Molmil](/molmil-images/mine/7vui) | Cryo-EM structure of a class A orphan GPCR | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Chimera of Endo-1,4-beta-xylanase and Probable G-protein coupled receptor 139, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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7VQX
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![BU of 7vqx by Molmil](/molmil-images/mine/7vqx) | Cryo-EM structure of human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Xu, Y.N, Feng, W.B, Zhou, Q.T, Liang, A.Y, Li, J, Dai, A.T, Zhao, F.H, Yan, J.H, Chen, C.W, Li, H, Zhao, L.H, Xia, T, Jiang, Y, Xu, H.E, Yang, D.H, Wang, M.W. | 登録日 | 2021-10-21 | 公開日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2. Nat Commun, 13, 2022
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7SHF
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![BU of 7shf by Molmil](/molmil-images/mine/7shf) | Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex | 分子名称: | (2S)-1-{[(S)-hydroxy{[(1s,2R,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, ... | 著者 | Patil, D.N, Singh, S, Singh, A.K, Martemyanov, K.A. | 登録日 | 2021-10-08 | 公開日 | 2021-12-01 | 最終更新日 | 2022-01-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex. Science, 375, 2022
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7PWD
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![BU of 7pwd by Molmil](/molmil-images/mine/7pwd) | Structure of an inhibited GRK2-G-beta and G-gamma complex | 分子名称: | 4-chloranyl-N-[2-(4-chlorophenyl)ethyl]thieno[2,3-c]pyridine-2-carboxamide, Beta-adrenergic receptor kinase 1, CHLORIDE ION, ... | 著者 | Faucher, N, Tauchert, M.J, Konz Makino, D.L, Vuillard, L.M. | 登録日 | 2021-10-06 | 公開日 | 2021-10-20 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors Monatsh Chem, 2022
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7SF8
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![BU of 7sf8 by Molmil](/molmil-images/mine/7sf8) | GPR56 (ADGRG1) 7TM domain bound to tethered agonist in complex with G protein heterotrimer | 分子名称: | G protein subunit 13 (Gi2-mini-G13 chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Barros-Alvarez, X, Panova, O, Skiniotis, G. | 登録日 | 2021-10-03 | 公開日 | 2022-04-27 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | The tethered peptide activation mechanism of adhesion GPCRs. Nature, 604, 2022
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7SF7
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![BU of 7sf7 by Molmil](/molmil-images/mine/7sf7) | LPHN3 (ADGRL3) 7TM domain bound to tethered agonist in complex with G protein heterotrimer | 分子名称: | G protein subunit 13 (Gi2-mini-G13 chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Barros-Alvarez, X, Panova, O, Skiniotis, G. | 登録日 | 2021-10-03 | 公開日 | 2022-04-27 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | The tethered peptide activation mechanism of adhesion GPCRs. Nature, 604, 2022
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7VLA
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![BU of 7vla by Molmil](/molmil-images/mine/7vla) | Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex | 分子名称: | C-C chemokine receptor type 1, CCL15(27-92), CHOLESTEROL, ... | 著者 | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | 登録日 | 2021-10-02 | 公開日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nat.Chem.Biol., 18, 2022
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7VL8
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![BU of 7vl8 by Molmil](/molmil-images/mine/7vl8) | Cryo-EM structure of the Apo CCR1-Gi complex | 分子名称: | C-C chemokine receptor type 1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | 登録日 | 2021-10-02 | 公開日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nat.Chem.Biol., 18, 2022
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7VL9
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![BU of 7vl9 by Molmil](/molmil-images/mine/7vl9) | Cryo-EM structure of the CCL15(26-92) bound CCR1-Gi complex | 分子名称: | C-C chemokine receptor type 1, CCL15(26-92), CHOLESTEROL, ... | 著者 | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | 登録日 | 2021-10-02 | 公開日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nat.Chem.Biol., 18, 2022
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7VKT
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![BU of 7vkt by Molmil](/molmil-images/mine/7vkt) | cryo-EM structure of LTB4-bound BLT1 in complex with Gi protein | 分子名称: | CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Y, Wang, N. | 登録日 | 2021-10-01 | 公開日 | 2022-03-09 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of leukotriene B4 receptor 1 activation. Nat Commun, 13, 2022
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