7SF7

LPHN3 (ADGRL3) 7TM domain bound to tethered agonist in complex with G protein heterotrimer

Summary for 7SF7

• Entry DOI: 10.2210/pdb7sf7/pdb
• EMDB information: 25076 25077
• Descriptor: Isoform 1 of Adhesion G protein-coupled receptor L3, G protein subunit 13 (Gi2-mini-G13 chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
• Functional Keywords: adhesion gpcr, lphn3, latrophilin, adgrl3, tethered agonist, stalk, stachel, minig13, g13 heterotrimer, g protein, cryoem, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 106166.21

Authors

Barros-Alvarez, X.,Panova, O.,Skiniotis, G. (deposition date: 2021-10-03, release date: 2022-04-27, Last modification date: 2022-05-11)

• Primary citation: Barros-Alvarez, X.,Nwokonko, R.M.,Vizurraga, A.,Matzov, D.,He, F.,Papasergi-Scott, M.M.,Robertson, M.J.,Panova, O.,Yardeni, E.H.,Seven, A.B.,Kwarcinski, F.E.,Su, H.,Peroto, M.C.,Meyerowitz, J.G.,Shalev-Benami, M.,Tall, G.G.,Skiniotis, G.; The tethered peptide activation mechanism of adhesion GPCRs.; Nature, 604:757-762, 2022; PubMed: 35418682; DOI: 10.1038/s41586-022-04575-7

Experimental method

ELECTRON MICROSCOPY (2.9 Å)