7VVN

PTH-bound human PTH1R in complex with Gs (class4)

Summary for 7VVN

• Entry DOI: 10.2210/pdb7vvn/pdb
• EMDB information: 32145
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: g protein-coupled receptor, membrane protein, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 163953.59

Authors

Kobayashi, K.,Kusakizako, T.,Miyauchi, H.,Tomita, A.,Kobayashi, K.,Shihoya, W.,Yamashita, K.,Nishizawa, T.,Kato, H.E.,Nureki, O. (deposition date: 2021-11-06, release date: 2022-08-03, Last modification date: 2023-02-15)

• Primary citation: Kobayashi, K.,Kawakami, K.,Kusakizako, T.,Miyauchi, H.,Tomita, A.,Kobayashi, K.,Shihoya, W.,Yamashita, K.,Nishizawa, T.,Kato, H.E.,Inoue, A.,Nureki, O.; Endogenous ligand recognition and structural transition of a human PTH receptor.; Mol.Cell, 82:3468-3483.e5, 2022; PubMed: 35932760; DOI: 10.1016/j.molcel.2022.07.003

Experimental method

ELECTRON MICROSCOPY (3.8 Å)