7VUJ

Cryo-EM structure of a class A orphan GPCR

Summary for 7VUJ

• Entry DOI: 10.2210/pdb7vuj/pdb
• EMDB information: 32130
• Descriptor: Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (8 entities in total)
• Functional Keywords: orphan g protein coupled-receptor, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 155102.78

Authors

Liu, Z.J.,Hua, T.,Zhou, Y.L.,Wu, L.J. (deposition date: 2021-11-02, release date: 2021-12-29, Last modification date: 2024-10-23)

• Primary citation: Zhou, Y.,Daver, H.,Trapkov, B.,Wu, L.,Wu, M.,Harpsoe, K.,Gentry, P.R.,Liu, K.,Larionova, M.,Liu, J.,Chen, N.,Brauner-Osborne, H.,Gloriam, D.E.,Hua, T.,Liu, Z.J.; Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.; Cell Res., 32:210-213, 2022; PubMed: 34916631; DOI: 10.1038/s41422-021-00591-w

Experimental method

ELECTRON MICROSCOPY (3.8 Å)