7VUG

Cryo-EM structure of a class A orphan GPCR in complex with Gi

Summary for 7VUG

Entry DOI	10.2210/pdb7vug/pdb
EMDB information	32127
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	orphan g protein coupled-receptor, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	5
Total formula weight	175182.42
Authors	Liu, Z.J.,Hua, T.,Zhou, Y.L.,Wu, L.J. (deposition date: 2021-11-02, release date: 2021-12-29, Last modification date: 2022-02-16)
Primary citation	Zhou, Y.,Daver, H.,Trapkov, B.,Wu, L.,Wu, M.,Harpsoe, K.,Gentry, P.R.,Liu, K.,Larionova, M.,Liu, J.,Chen, N.,Brauner-Osborne, H.,Gloriam, D.E.,Hua, T.,Liu, Z.J. Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32:210-213, 2022 Cited by PubMed: 34916631 DOI: 10.1038/s41422-021-00591-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation