PDB: 902 件ウェブページステータス検索Chemie searchBIRD

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7YS6	Cryo-EM structure of the Serotonin 6 (5-HT6) receptor-DNGs-scFv16 complex 分子名称: 5-hydroxytryptamine receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhao, Q.Y, Wang, Y.F, He, L, Wang, S, Cong, Y. 登録日 2022-08-11 公開日 2023-03-29 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into constitutive activity of 5-HT 6 receptor. Proc.Natl.Acad.Sci.USA, 120, 2023
8FN0	CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator 分子名称: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. 登録日 2022-12-26 公開日 2023-03-29 最終更新日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
8FN1	CryoEM structure of Go-coupled NTSR1 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... 著者 Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. 登録日 2022-12-26 公開日 2023-03-29 最終更新日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
8FMZ	Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, MiniGq, ... 著者 Krumm, B.E, Diberto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. 登録日 2022-12-26 公開日 2023-03-29 最終更新日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.59 Å) 主引用文献 Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
7F6G	Cryo-EM structure of human angiotensin receptor AT1R in complex Gq proteins and Sar1-AngII 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin receptor AT1R, CHOLESTEROL, ... 著者 Zhang, D, Xu, L, Zhan, Y, Guo, J, Zhang, H. 登録日 2021-06-25 公開日 2023-03-29 最終更新日 2023-10-18 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists. Embo J., 42, 2023
8FU6	GCGR-Gs complex in the presence of RAMP2 分子名称: Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Krishna Kumar, K, O'Brien, E.S, Wang, H, Montabana, E, Kobilka, B.K. 登録日 2023-01-16 公開日 2023-04-12 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Negative allosteric modulation of the glucagon receptor by RAMP2. Cell, 186, 2023
8IBV	Cryo-EM structure of the motilin-bound motilin receptor-Gq protein complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... 著者 Jiang, Y, Xu, H.E, You, C, Xu, Y. 登録日 2023-02-10 公開日 2023-04-12 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 Structural basis for motilin and erythromycin recognition by motilin receptor. Sci Adv, 9, 2023
8IBU	Cryo-EM structure of the erythromycin-bound motilin receptor-Gq protein complex 分子名称: ERYTHROMYCIN A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 You, C, Jiang, Y, Xu, H.E, Xu, Y. 登録日 2023-02-10 公開日 2023-04-12 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.51 Å) 主引用文献 Structural basis for motilin and erythromycin recognition by motilin receptor. Sci Adv, 9, 2023
8G94	Structure of CD69-bound S1PR1 coupled to heterotrimeric Gi 分子名称: Early activation antigen CD69, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Chen, H, Li, X. 登録日 2023-02-21 公開日 2023-04-19 最終更新日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Transmembrane protein CD69 acts as an S1PR1 agonist. Elife, 12, 2023
7YAC	Paltusotine-bound SSTR2-Gi complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Zhao, J, Shao, Z. 登録日 2022-06-27 公開日 2023-04-19 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nat Commun, 14, 2023
7YKD	Cryo-EM structure of the human chemerin receptor 1 complex with the C-terminal nonapeptide of chemerin 分子名称: CHOLESTEROL, Chemerin-like receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Chen, G, Liao, Q, Ye, R.D, Wang, J. 登録日 2022-07-22 公開日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin. Proc.Natl.Acad.Sci.USA, 120, 2023
7YAE	Octreotide-bound SSTR2-Gi complex 分子名称: CHOLESTEROL, DPN-CYS-PHE-DTR-LYS-THR-CYS-THO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhao, J, Shao, Z. 登録日 2022-06-28 公開日 2023-04-19 実験手法 ELECTRON MICROSCOPY (3.37 Å) 主引用文献 Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nat Commun, 14, 2023
8FLR	Human PTH1R in complex with PTHrP and Gs 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. 登録日 2022-12-22 公開日 2023-04-26 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
8FLQ	Human PTH1R in complex with PTH(1-34) and Gs 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. 登録日 2022-12-22 公開日 2023-04-26 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (2.55 Å) 主引用文献 Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
8FLS	Human PTH1R in complex with Abaloparatide and Gs 分子名称: Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. 登録日 2022-12-22 公開日 2023-04-26 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
8FLT	Human PTH1R in complex with M-PTH(1-14) and Gs 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. 登録日 2022-12-22 公開日 2023-04-26 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
8FLU	Human PTH1R in complex with LA-PTH and Gs 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. 登録日 2022-12-22 公開日 2023-04-26 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
8DZR	GR89,696 bound Kappa Opioid Receptor in complex with gustducin 分子名称: G alpha gustducin protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (2.61 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
8DZS	GR89,696 bound Kappa Opioid Receptor in complex with Gz 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(z) subunit alpha, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.65 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
8DZP	momSalB bound Kappa Opioid Receptor in complex with Gi1 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.71 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
8DZQ	momSalB bound Kappa Opioid Receptor in complex with GoA 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... 著者 Fay, J.F, Che, T. 登録日 2022-08-08 公開日 2023-05-03 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (2.82 Å) 主引用文献 Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
7XJJ	Cryo-EM structure of the galanin-bound GALR1-miniGo complex 分子名称: G protein subunit alpha o1,Guanine nucleotide-binding protein G(o) subunit alpha, Galanin, Galanin receptor type 1, ... 著者 Jiang, W, Zheng, S. 登録日 2022-04-18 公開日 2023-05-03 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural insights into galanin receptor signaling. Proc.Natl.Acad.Sci.USA, 119, 2022
7XY7	Adenosine receptor bound to a non-selective agonist in complex with a G protein obtained by cryo-EM 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. 登録日 2022-05-31 公開日 2023-05-03 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Sci Adv, 8, 2022
7XY6	Adenosine receptor bound to an agonist in complex with G protein obtained by cryo-EM 分子名称: 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. 登録日 2022-05-31 公開日 2023-05-03 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (2.99 Å) 主引用文献 Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Sci Adv, 8, 2022
8G2Y	Cryo-EM structure of ADGRF1 coupled to miniGs/q 分子名称: Adhesion G-protein-coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Jones, D, Rawson, S, Blacklow, S. 登録日 2023-02-06 公開日 2023-05-10 実験手法 ELECTRON MICROSCOPY (3.44 Å) 主引用文献 Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling. Nat Commun, 14, 2023

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