7YAC

Paltusotine-bound SSTR2-Gi complex

Summary for 7YAC

Entry DOI	10.2210/pdb7yac/pdb
EMDB information	33708
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	agonist, membrane protein, complex, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	152390.08
Authors	Zhao, J.,Shao, Z. (deposition date: 2022-06-27, release date: 2023-04-19, Last modification date: 2023-09-27)
Primary citation	Zhao, J.,Fu, H.,Yu, J.,Hong, W.,Tian, X.,Qi, J.,Sun, S.,Zhao, C.,Wu, C.,Xu, Z.,Cheng, L.,Chai, R.,Yan, W.,Wei, X.,Shao, Z. Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nat Commun, 14:962-962, 2023 Cited by PubMed: 36810324 DOI: 10.1038/s41467-023-36673-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.24 Å)

Structure validation