7YAC
Paltusotine-bound SSTR2-Gi complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (E) | Somatostatin receptor type 2 | polymer | 332 | 37339.4 | 1 | UniProt (P30874) Pfam (PF00001) | Homo sapiens (human) | SS-2-R,SS2-R,SS2R,SST2,SRIF-1 |
| 5 | E (S) | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus | ||
| 6 | F (E) | Paltusotine | non-polymer | 456.5 | 1 | Chemie (IUD) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
E: 31 - 338 (UniProt: P30874)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | engineered mutation |
| Ala 203 | Gly 203 | engineered mutation |
| Ala 245 | Glu 245 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | initiating methionine |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 7 | - | initiating methionine |
| Lys 8 | - | expression tag |
| Thr 9 | - | expression tag |
| Ile 10 | - | expression tag |
| Ile 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Leu 13 | - | expression tag |
| Ser 14 | - | expression tag |
| Tyr 15 | - | expression tag |
| Ile 16 | - | expression tag |
| Phe 17 | - | expression tag |
| Cys 18 | - | expression tag |
| Leu 19 | - | expression tag |
| Val 20 | - | expression tag |
| Phe 21 | - | expression tag |
| Ala 22 | - | expression tag |
| Asp 23 | - | expression tag |
| Tyr 24 | - | expression tag |
| Lys 25 | - | expression tag |
| Asp 26 | - | expression tag |
| Asp 27 | - | expression tag |
| Asp 28 | - | expression tag |
| Asp 29 | - | expression tag |
| Ala 30 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 151933.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 456.5 | |
| All* | Total formula weight | 152390.1 |
