8GSG
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8EZ0
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation | 分子名称: | Insulin, Insulin receptor | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | 登録日 | 2022-10-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EYX
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Asymmetric conformation 1 | 分子名称: | Insulin, Insulin receptor | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | 登録日 | 2022-10-29 | 公開日 | 2022-11-09 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EYR
| Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation | 分子名称: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | 登録日 | 2022-10-28 | 公開日 | 2022-11-09 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EYY
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2 | 分子名称: | Insulin, Insulin receptor | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | 登録日 | 2022-10-29 | 公開日 | 2022-11-09 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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7U6E
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7RZI
| Insulin Degrading Enzyme pC/pC | 分子名称: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | 登録日 | 2021-08-27 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZE
| Insulin Degrading Enzyme pO/pC | 分子名称: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | 登録日 | 2021-08-27 | 公開日 | 2022-08-31 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZF
| Insulin Degrading Enzyme O/pC | 分子名称: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | 登録日 | 2021-08-27 | 公開日 | 2022-08-31 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7V3P
| Cryo-EM structure of the IGF1R/insulin complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | 著者 | Zhang, J, Liu, C, Zhang, X, Wei, T, Wu, C. | 登録日 | 2021-08-11 | 公開日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of the IGF1R/insulin complex To Be Published
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7WRQ
| Structure of Human IGF1/IGFBP3/ALS Ternary Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor-binding protein 3, Insulin-like growth factor-binding protein complex acid labile subunit, ... | 著者 | Kim, H, Fu, Y, Kim, H.M. | 登録日 | 2022-01-27 | 公開日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex Nat Commun, 13, 2022
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7RKD
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7S0Q
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7QGF
| Cubic Insulin SAD phasing at 14.2 keV | 分子名称: | Insulin A chain, Insulin B chain | 著者 | Nanao, M.H, Basu, S. | 登録日 | 2021-12-08 | 公開日 | 2022-06-01 | 実験手法 | X-RAY DIFFRACTION (1.203 Å) | 主引用文献 | ID23-2: an automated and high-performance microfocus beamline for macromolecular crystallography at the ESRF. J.Synchrotron Radiat., 29, 2022
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7STJ
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7STH
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7STK
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7STI
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7SL2
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7SL6
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7SL3
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7SL7
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7SL4
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7SL1
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7MD5
| Insulin receptor ectodomain dimer complexed with two IRPA-9 partial agonists | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gomez-Llorente, Y, Zhou, H, Scapin, G. | 登録日 | 2021-04-03 | 公開日 | 2022-02-23 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13, 2022
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