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7STK

Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 2)

Summary for 7STK
Entry DOI10.2210/pdb7stk/pdb
EMDB information25188 25189 25190 25191 25192 25193 25428 25429 25430 25431
DescriptorInsulin receptor, Insulin (2 entities in total)
Functional Keywordsinsulin receptor, site 1 binding deficient mutant insulin, signaling protein
Biological sourceMus musculus (house mouse)
More
Total number of polymer chains4
Total formula weight335560.76
Authors
Bai, X.C.,Choi, E. (deposition date: 2021-11-14, release date: 2022-03-30, Last modification date: 2022-04-27)
Primary citationLi, J.,Park, J.,Mayer, J.P.,Webb, K.J.,Uchikawa, E.,Wu, J.,Liu, S.,Zhang, X.,Stowell, M.H.B.,Choi, E.,Bai, X.C.
Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29:357-368, 2022
Cited by
PubMed: 35361965
DOI: 10.1038/s41594-022-00750-6
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (4 Å)
Structure validation

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