7RZI

Insulin Degrading Enzyme pC/pC

Summary for 7RZI

Entry DOI	10.2210/pdb7rzi/pdb
Related	7RZE 7RZF 7RZG 7RZH
EMDB information	24761
Descriptor	Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain (3 entities in total)
Functional Keywords	m16a zinc metalloprotease, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	245740.27
Authors	Mancl, J.M.,Liang, W.G.,Tang, W.J. (deposition date: 2021-08-27, release date: 2022-08-31)
Primary citation	Mancl, J.M.,Liang, W.G.,Wei, H.,Carragher, B.,Potter, C.S.,Tang, W.J. Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published,
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation