1UEC
 
 | | Crystal structure of autoinhibited form of tandem SH3 domain of p47phox | | 分子名称: | Neutrophil cytosol factor 1 | | 著者 | Yuzawa, S, Suzuki, N.N, Fujioka, Y, Ogura, K, Sumimoto, H, Inagaki, F. | | 登録日 | 2003-05-11 | | 公開日 | 2003-05-27 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase
Genes Cells, 9, 2004
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1W70
 | | SH3 domain of p40phox complexed with C-terminal polyProline region of p47phox | | 分子名称: | NEUTROPHIL CYTOSOL FACTOR 1, NEUTROPHIL CYTOSOL FACTOR 4, SULFATE ION, ... | | 著者 | Massenet, C, Chenavas, S, Cohen-Addad, C, Dagher, M.-C, Brandolin, G, Pebay-Peyroula, E, Fieschi, F. | | 登録日 | 2004-08-26 | | 公開日 | 2005-01-18 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | Effects of P47Phox C-Terminus Phosphorylation on Binding Interactions with P40Phox and P67Phox: Structural and Functional Comparison of P40Phox P67Phox SH3 Domains
J.Biol.Chem., 280, 2005
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1YCS
 | | P53-53BP2 COMPLEX | | 分子名称: | 53BP2, P53, ZINC ION | | 著者 | Gorina, S, Pavletich, N.P. | | 登録日 | 1996-09-30 | | 公開日 | 1997-11-19 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.
Science, 274, 1996
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2DX1
 | | Crystal structure of RhoGEF protein Asef | | 分子名称: | Rho guanine nucleotide exchange factor 4 | | 著者 | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2006-08-22 | | 公開日 | 2007-01-02 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism
J.Biol.Chem., 282, 2007
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2DYB
 | | The crystal structure of human p40(phox) | | 分子名称: | Neutrophil cytosol factor 4 | | 著者 | Honbou, K. | | 登録日 | 2006-09-08 | | 公開日 | 2007-01-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding.
Embo J., 26, 2007
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2JT4
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2KNB
 | | Solution NMR structure of the parkin Ubl domain in complex with the endophilin-A1 SH3 domain | | 分子名称: | E3 ubiquitin-protein ligase parkin, Endophilin-A1 | | 著者 | Trempe, J, Guennadi, K, Edna, C.M, Kalle, G. | | 登録日 | 2009-08-20 | | 公開日 | 2009-12-22 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination.
Mol.Cell, 36, 2009
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2KBT
 | | Attachment of an NMR-invisible solubility enhancement tag (INSET) using a sortase-mediated protein ligation method | | 分子名称: | Proto-oncogene vav,Immunoglobulin G-binding protein G | | 著者 | Kumeta, H, Kobashigawa, Y, Ogura, K, Inagaki, F. | | 登録日 | 2008-12-07 | | 公開日 | 2009-02-03 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Attachment of an NMR-invisible solubility enhancement tag using a sortase-mediated protein ligation method
J.Biomol.Nmr, 43, 2009
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2L3S
 | | Structure of the autoinhibited Crk | | 分子名称: | Autoinhibited Crk protein | | 著者 | Kalodimos, C.G, Sarkar, P, Saleh, T, Tzeng, S.R, Birge, R. | | 登録日 | 2010-09-21 | | 公開日 | 2010-12-08 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for regulation of the Crk signaling protein by a proline switch.
Nat.Chem.Biol., 7, 2011
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3UF4
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4U5W
 | | Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Protein Nef, ... | | 著者 | Alvarado, J.J, Yeh, J.I, Smithgall, T.E. | | 登録日 | 2014-07-25 | | 公開日 | 2014-08-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment.
J.Biol.Chem., 289, 2014
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6PBC
 | | Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION | | 著者 | Hajicek, N, Sondek, J. | | 登録日 | 2019-06-13 | | 公開日 | 2020-01-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations.
Elife, 8, 2019
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4XI2
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7YQE
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6F3F
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7Z3J
 | | Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | | 著者 | Pinotsis, N, Bunney, T.D, Katan, M. | | 登録日 | 2022-03-02 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme.
Sci Adv, 8, 2022
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5MO4
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7T8T
 | | CryoEM structure of PLCg1 | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, CALCIUM ION | | 著者 | Endo-Streeter, S, Sondek, J. | | 登録日 | 2021-12-17 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | CryoEM structure of PLCg1
To Be Published
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7UY3
 | | Crystal structure of human Fgr tyrosine kinase in complex with TL02-59 | | 分子名称: | 1,2-ETHANEDIOL, 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide, GLYCEROL, ... | | 著者 | Du, S, Alvarado, J.J, Smithgall, T.E. | | 登録日 | 2022-05-06 | | 公開日 | 2022-12-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr.
Structure, 30, 2022
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7UY0
 | | Crystal structure of human Fgr tyrosine kinase in complex with A-419259 | | 分子名称: | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CHLORIDE ION, GLYCEROL, ... | | 著者 | Du, S, Alvarado, J.J, Smithgall, T.E. | | 登録日 | 2022-05-06 | | 公開日 | 2022-12-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr.
Structure, 30, 2022
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8GMB
 | | Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible) | | 分子名称: | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, Tyrosine-protein kinase BTK | | 著者 | Lin, D.Y, Andreotti, A.H. | | 登録日 | 2023-03-24 | | 公開日 | 2023-08-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.
Elife, 12, 2024
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8SSN
 | | Abl kinase in complex with SKI and asciminib | | 分子名称: | 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Ludewig, H, Kim, C, Kern, D. | | 登録日 | 2023-05-08 | | 公開日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | A biophysical framework for double-drugging kinases.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8T7C
 | | Crystal structure of human phospholipase C gamma 2 | | 分子名称: | 1,2-ETHANEDIOL, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, CALCIUM ION | | 著者 | Chen, Y, Choi, H, Zhuang, N, Hu, L, Qian, D, Wang, J. | | 登録日 | 2023-06-20 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | The crystal and cryo-EM structures of PLCg2 reveal dynamic inter-domain recognitions in autoinhibition
To Be Published
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8DGQ
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8DGO
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