7UY3

Crystal structure of human Fgr tyrosine kinase in complex with TL02-59

Summary for 7UY3

Entry DOI	10.2210/pdb7uy3/pdb
Descriptor	Tyrosine-protein kinase Fgr, 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	fgr, tl02-59, signaling protein, kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	53195.00
Authors	Du, S.,Alvarado, J.J.,Smithgall, T.E. (deposition date: 2022-05-06, release date: 2022-12-28, Last modification date: 2023-11-15)
Primary citation	Du, S.,Alvarado, J.J.,Wales, T.E.,Moroco, J.A.,Engen, J.R.,Smithgall, T.E. ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30:1508-1517.e3, 2022 Cited by PubMed: 36115344 DOI: 10.1016/j.str.2022.08.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.99 Å)

Structure validation