7UY3
Crystal structure of human Fgr tyrosine kinase in complex with TL02-59
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase Fgr | polymer | 456 | 52241.3 | 1 | UniProt (P09769) Pfam (PF00018) Pfam (PF00017) Pfam (PF07714) | Homo sapiens (human) | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog,Proto-oncogene c-Fgr,p55-Fgr,p58-Fgr,p58c-Fgr |
| 2 | B (A) | 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide | non-polymer | 609.6 | 1 | Chemie (OJL) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E, F (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) |
Sequence modifications
A: 84 - 531 (UniProt: P09769)
| PDB | External Database | Details |
|---|---|---|
| Met 76 | - | initiating methionine |
| Gly 77 | - | expression tag |
| His 78 | - | expression tag |
| His 79 | - | expression tag |
| His 80 | - | expression tag |
| His 81 | - | expression tag |
| His 82 | - | expression tag |
| His 83 | - | expression tag |
| Glu 528 | Gln 524 | engineered mutation |
| Glu 529 | Pro 525 | engineered mutation |
| Ile 530 | Gly 526 | engineered mutation |
| Pro 531 | Asp 527 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52241.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 953.7 | |
| All* | Total formula weight | 53195.0 |
