4U5W

Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains

Summary for 4U5W

Entry DOI	10.2210/pdb4u5w/pdb
Descriptor	Protein Nef, Tyrosine-protein kinase HCK, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
Functional Keywords	hck, sh3-sh2 regulatory domains, sh3, sh2, src family kinase, sfk, hiv-1, nef, virus, protein-protein complex, nef-hck complex, viral protein-transferase complex, viral protein/transferase
Biological source	Human immunodeficiency virus type 1 (HIV-1) More
Total number of polymer chains	4
Total formula weight	77786.27
Authors	Alvarado, J.J.,Yeh, J.I.,Smithgall, T.E. (deposition date: 2014-07-25, release date: 2014-08-20, Last modification date: 2023-09-27)
Primary citation	Alvarado, J.J.,Tarafdar, S.,Yeh, J.I.,Smithgall, T.E. Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment. J.Biol.Chem., 289:28539-28553, 2014 Cited by PubMed: 25122770 DOI: 10.1074/jbc.M114.600031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation