PDB: 479 件ウェブページステータス検索Chemie searchBIRD

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3D3F	Crystal Structure of Yvgn and cofactor NADPH from Bacillus subtilis 分子名称: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, YvgN protein 著者 Zhou, Y.F, Lei, J, Su, X.D. 登録日 2008-05-10 公開日 2009-04-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and biochemical analyses of YvgN and YtbE from Bacillus subtilis Protein Sci., 18, 2009
3DN5	Aldose Reductase in complex with novel biarylic inhibitor 分子名称: 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Steuber, H, Klebe, G. 登録日 2008-07-01 公開日 2009-04-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure-Based Optimization of Aldose Reductase Inhibitors Originating from Virtual Screening Chemmedchem, 4, 2009
3GHR	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. First stage of radiation damage 分子名称: Aldose reductase, CITRIC ACID, IDD594, ... 著者 Petrova, T, Ginell, S, Hazemann, I, Mitschler, A, Podjarny, A, Joachimiak, A. 登録日 2009-03-04 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 X-ray-radiation-induced cooperative atomic movements in protein. J.Mol.Biol., 387, 2009
3G5E	Human aldose reductase complexed with IDD 740 inhibitor 分子名称: 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid, Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Podjarny, A.D, Van Zandt, M.C. 登録日 2009-02-05 公開日 2009-03-24 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. Bioorg.Med.Chem.Lett., 19, 2009
3GHU	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Forth stage of radiation damage. 分子名称: Aldose reductase, CITRIC ACID, IDD594, ... 著者 Petrova, T, Ginell, S, Hazemann, I, Mitschler, A, Podjarny, A, Joachimiak, A. 登録日 2009-03-04 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 X-ray-radiation-induced cooperative atomic movements in protein. J.Mol.Biol., 387, 2009
3GHS	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Second stage of radiation damage. 分子名称: Aldose reductase, CITRIC ACID, IDD594, ... 著者 Petrova, T, Ginell, S, Hazemann, I, Mitschler, A, Podjarny, A, Joachimiak, A. 登録日 2009-03-04 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 X-ray-radiation-induced cooperative atomic movements in protein. J.Mol.Biol., 387, 2009
3GHT	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Third stage of radiation damage. 分子名称: Aldose reductase, CITRIC ACID, IDD594, ... 著者 Petrova, T, Ginell, S, Hazemann, I, Mitschler, A, Podjarny, A, Joachimiak, A. 登録日 2009-03-04 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 X-ray-radiation-induced cooperative atomic movements in protein. J.Mol.Biol., 387, 2009
3CV6	The crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase GG225.226PP mutant in complex with inhibitor and cofactor NADP+. 分子名称: 4-[(1R,2S)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol, Aldo-keto reductase family 1 member C21, BETA-MERCAPTOETHANOL, ... 著者 Dhagat, U, El-Kabbani, O. 登録日 2008-04-17 公開日 2009-03-03 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate. Acta Crystallogr.,Sect.D, 65, 2009
2R24	Human Aldose Reductase structure 分子名称: Aldose reductase, IDD594, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Blakeley, M.P, Ruiz, F, Cachau, R, Hazemann, I, Meilleur, F, Mitschler, A, Ginell, S, Afonine, P, Ventura, O.N, Cousido-Siah, A, Haertlein, M, Joachimiak, A, Myles, D, Podjarny, A. 登録日 2007-08-24 公開日 2008-12-23 最終更新日 2024-02-21 実験手法 NEUTRON DIFFRACTION (1.752 Å), X-RAY DIFFRACTION 主引用文献 Quantum model of catalysis based on mobile proton revealed by subatomic X-Ray and neutron diffraction studies of h-Aldose Reductase Proc.Natl.Acad.Sci.USA, 105, 2008
3CAS	Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 4-androstenedione 分子名称: 1,2-ETHANEDIOL, 3-oxo-5-beta-steroid 4-dehydrogenase, 4-ANDROSTENE-3-17-DIONE, ... 著者 Faucher, F, Cantin, L, Breton, R. 登録日 2008-02-20 公開日 2008-12-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structures of Human Delta4-3-Ketosteroid 5beta-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition (dagger) (,) (double dagger). Biochemistry, 47, 2008
3CAQ	Crystal structure of 5beta-reductase (AKR1D1) in complex with NADPH 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 3-oxo-5-beta-steroid 4-dehydrogenase, ... 著者 Faucher, F, Cantin, L, Breton, R. 登録日 2008-02-20 公開日 2008-12-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structures of Human Delta4-3-Ketosteroid 5beta-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition (dagger) (,) (double dagger). Biochemistry, 47, 2008
3F7J	B.subtilis YvgN 分子名称: NITRATE ION, POTASSIUM ION, YvgN protein 著者 Zhou, Y.F, Lei, J, Liang, Y.H, Su, X.-D. 登録日 2008-11-09 公開日 2008-11-25 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and biochemical analyses of YvgN and YtbE from Bacillus subtilis Protein Sci., 18, 2009
3ERP	Structure of IDP01002, a putative oxidoreductase from and essential gene of Salmonella typhimurium 分子名称: 1,2-ETHANEDIOL, CACODYLATE ION, CHLORIDE ION, ... 著者 Singer, A.U, Minasov, G, Evdokimova, E, Brunzelle, J.S, Kudritska, M, Edwards, A.M, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2008-10-02 公開日 2008-11-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural and biochemical studies of novel aldo-keto reductases for the biocatalytic conversion of 3-hydroxybutanal to 1,3-butanediol. Appl.Environ.Microbiol., 2017
3CV7	Crystal structure of porcine aldehyde reductase ternary complex 分子名称: 3,5-dichloro-2-hydroxybenzoic acid, Alcohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Carbone, V, El-Kabbani, O. 登録日 2008-04-18 公開日 2008-10-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.412 Å) 主引用文献 Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity Arch.Biochem.Biophys., 479, 2008
3DOP	Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 5beta-dihydrotestosterone, Resolution 2.00A 分子名称: 3-oxo-5-beta-steroid 4-dehydrogenase, 5-beta-DIHYDROTESTOSTERONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Di Costanzo, L, Drury, J.E, Penning, T.M, Christianson, D.W. 登録日 2008-07-05 公開日 2008-10-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure and catalytic mechanism of human steroid 5beta-reductase (AKR1D1) Mol.Cell.Endocrinol., 301, 2009
3B3D	B.subtilis YtbE 分子名称: CALCIUM ION, Putative morphine dehydrogenase 著者 Zhou, Y.F, Li, L.F, Liang, Y.H, Su, X.-D. 登録日 2007-10-20 公開日 2008-10-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and biochemical analyses of YvgN and YtbE from Bacillus subtilis Protein Sci., 18, 2009
3EB3	Voltage-dependent K+ channel beta subunit (W121A) in complex with cortisone 分子名称: 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Voltage-gated potassium channel subunit beta-2 著者 Pan, Y, Weng, J, Kabaleeswaran, V, Li, H, Cao, Y, Bhosle, R.C, Zhou, M. 登録日 2008-08-26 公開日 2008-09-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Cortisone dissociates the Shaker family K+ channels from their beta subunits. Nat.Chem.Biol., 4, 2008
3EAU	Voltage-dependent K+ channel beta subunit in complex with cortisone 分子名称: 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Voltage-gated potassium channel subunit beta-2 著者 Pan, Y, Weng, J, Kabaleeswaran, V, Li, H, Cao, Y, Bhosle, R.C, Zhou, M. 登録日 2008-08-26 公開日 2008-09-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Cortisone dissociates the Shaker family K+ channels from their beta subunits. Nat.Chem.Biol., 4, 2008
3EB4	Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone 分子名称: 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Voltage-gated potassium channel subunit beta-2 著者 Pan, Y, Weng, J, Kabaleeswaran, V, Li, H, Cao, Y, Bhosle, R.C, Zhou, M. 登録日 2008-08-26 公開日 2008-09-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Cortisone dissociates the Shaker family K+ channels from their beta subunits. Nat.Chem.Biol., 4, 2008
3C3U	Crystal structure of AKR1C1 in complex with NADP and 3,5-dichlorosalicylic acid 分子名称: 3,5-dichloro-2-hydroxybenzoic acid, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Dhagat, U, El-Kabbani, O. 登録日 2008-01-28 公開日 2008-08-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid J.Med.Chem., 51, 2008
3CAV	Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 5beta-pregnan-3,20-dione 分子名称: (5BETA)-PREGNANE-3,20-DIONE, 1,2-ETHANEDIOL, 3-oxo-5-beta-steroid 4-dehydrogenase, ... 著者 Faucher, F, Cantin, L, Breton, R. 登録日 2008-02-20 公開日 2008-07-29 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. Biochemistry, 47, 2008
2PZN	The crystallographic structure of Aldose Reductase IDD393 complex confirms Leu300 as a specificity determinant 分子名称: (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Ruiz, F, Hazemann, I, Darmanin, C, Mitschler, A, Van Zandt, M, Joachimiak, A, El-Kabbani, O, Podjarny, A. 登録日 2007-05-18 公開日 2008-05-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 The Crystallographic Structure of Alr2-Idd393 Complex Confirms Leu300 as a Specificity Determinant To be Published
3COT	Crystal structure of human liver delta(4)-3-ketosteroid 5beta-reductase (akr1d1) in complex with progesterone and nadp. Resolution: 2.03 A. 分子名称: 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE 著者 Di Costanzo, L, Drury, J, Penning, T.M, Christianson, D.W. 登録日 2008-03-29 公開日 2008-04-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis. J.Biol.Chem., 283, 2008
3CMF	Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and CORTISONE. Resolution 1.90 A. 分子名称: 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Di Costanzo, L, Drury, J, Penning, T.M, Christianson, D.W. 登録日 2008-03-21 公開日 2008-04-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis. J.Biol.Chem., 283, 2008
3BCJ	Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A 分子名称: (2S,4R)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Aldose reductase, CITRIC ACID, ... 著者 Zhao, H.T, El-Kabbani, O. 登録日 2007-11-13 公開日 2008-04-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (0.78 Å) 主引用文献 Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 A Resolution: Implications for the Inhibition Mechanism J.Med.Chem., 51, 2008

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