Summary for 3BCJ
| Related | 1X98 1PWM |
|---|---|
| Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ... (5 entities in total) |
| Functional Keywords | aldo-keto reductases, diabetes, drug design, polyl pathway, acetylation, cataract, cytoplasm, nadp, oxidoreductase, polymorphism |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm P15121 |
| Total number of polymer chains | 1 |
| Total molecular weight | 37113.09 |
| Authors | Zhao, H.T.,El-Kabbani, O. (deposition date: 2007-11-13, release date: 2008-04-08, Last modification date: 2011-07-13) |
| Primary citation | Zhao, H.T.,Hazemann, I.,Mitschler, A.,Carbone, V.,Joachimiak, A.,Ginell, S.,Podjarny, A.,El-Kabbani, O. Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 A Resolution: Implications for the Inhibition Mechanism J.Med.Chem., 51:1478-1481, 2008 PubMed: 18284183 (PDB entries with the same primary citation) DOI: 10.1021/jm701514k  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (0.78 Å) |
