3BCJ

Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A

Summary for 3BCJ

Entry DOI	10.2210/pdb3bcj/pdb
Related	1PWM 1X98
Descriptor	Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ... (5 entities in total)
Functional Keywords	aldo-keto reductases, diabetes, drug design, polyl pathway, acetylation, cataract, cytoplasm, nadp, oxidoreductase, polymorphism
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37113.09
Authors	Zhao, H.T.,El-Kabbani, O. (deposition date: 2007-11-13, release date: 2008-04-08, Last modification date: 2023-11-01)
Primary citation	Zhao, H.T.,Hazemann, I.,Mitschler, A.,Carbone, V.,Joachimiak, A.,Ginell, S.,Podjarny, A.,El-Kabbani, O. Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 A Resolution: Implications for the Inhibition Mechanism J.Med.Chem., 51:1478-1481, 2008 Cited by PubMed: 18284183 DOI: 10.1021/jm701514k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.78 Å)

Structure validation